scioDiscover: Protein profiling & biomarker discovery

Proteomics service for pre-clinical research &

Protein biomarker discovery

Robust, comprehensive & fast

Our high-throughput protein profiling service supports researchers in identifying novel protein biomarkers, understanding disease mechanisms, and accelerating pre-clinical drug development.

Using our proprietary antibody microarray platform, we enable the simultaneous quantification of over 1,500 proteins from minimal sample volumes — ideal for biomarker discovery, pathway analysis, and protein profiling studies.

Partner with Sciomics – your specialized proteomics CRO – and take your biomarker discovery and pre-clinical research to the next level.

   

    Biomarker discovery
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Antibody Microarray Workflow for robust proteomics profiling: Illustration depicting the steps involved in protein profiling using antibody microarrays, from protein isolation and sample labeling to antibody immobilization, sample incubation, image acquisition, and data analysis for the scioDiscover platform.

The Assay

  • High-throughput immuno-based protein profiling using complex antibody microarrays
  • Ideal for pre-clinical protein biomarker discovery and pathway analysis
  • Broad coverage of key biological processes and signaling pathways
  • Native sample matrices (non-fractionated / non-depleted)
  • Highest sensitivity and reproducibility (CV <10%, 4 technical replicates) from minimal sample volumes
scioDiscover Proteomic Profiling and PTM Analysis: Diagram illustrating the applications of scioDiscover in biomarker discovery, disease model characterization, pathway activity analysis, drug target discovery, and mode of action studies. As your trusted CRO partner for immunobased proteomics, we offer end-to-end support – from study planning and sample analysis to comprehensive data interpretation. Whether you're exploring disease mechanisms or validating drug effects, our platform delivers actionable insights for your research success.

 

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 a scientist   

 

Data Analysis is included

  • In-depth bioinformatic analysis based on > 6,000 data points per sample
  • Protein interaction and pathway network mapping
  • Functional annotation and biological pathway classification
  • Data integration for different sample types

Application examples

  • Protein biomarker discovery
  • Pre-clinical and translational research
  • Pathway profiling and pathway regulation studies
  • Drug response profiling and mode-of-action studies
  • Patient stratification 
  • Basic research 

Compatible sample types

Our service supports a broad range of sample types – even in very limited amounts:

  • Plasma / Serum
  • Cerebrospinal fluid (CSF)
  • Interstitial fluid (ISF)
  • Urine
  • Saliva
  • Tissue lysates
  • Cell lysates / cultured cells
  • Cell culture supernatants
  • Organoids

If you are working with a different type of biological sample, feel free to contact our scientists – we are generally able to analyse any protein-containing sample

 

Publications using scioDiscover

Article | Exploration of Novel Biomarkers for Neurodegenerative Diseases

| December 2024 | Biomarker candidates for neurodegenerative diseases were identified by combining an exploratory proteomic approach with quantitative ligand-binding assays. Sciomics supported this study by proteomic screening of plasma and CSF samples of patients with different neurodegenerative diseases using the scioDiscover microarray platform.

Kenzelmann A, et al.. Exploration of Novel Biomarkers for Neurodegenerative Diseases Using Proteomic Analysis and Ligand-Binding Assays. Biomedicines. 2024;12(12):2794.  

Article | Vago-splenic signal transduction of cardioprotection in humans

| April 2024 | The spleen as a relay organ as well as the vagal innervation determine cardioprotective signal transduction of Remote Ischaemic Conditioning (RIC) and Auricular Tragus Stimulation (ATS). Sciomics contributed to this study by analysing plasma-dialysate samples using the scioDiscover microarray platform.

Lieder HR, Paket U, Skyschally A, et al. Vago-splenic signal transduction of cardioprotection in humans. Eur Heart J. 2024;45(34):3164-3177. 

Article | Predicting a severe Covid-19 disease

| April 2023 | New Article: In a protein biomarker development project initiated by Sciomics, we have identified protein biomarker panels predicting development of a severe Covid.19  disease.

Hufnagel K., Fathi A. et al. Discovery and systematic assessment of early biomarkers that predict progression to severe COVID-19 disease. Communications Medicine 3,51 (2023)

Article | Microbiota influences chemotherapy in pancreatic cancer

| February 2023 | New Article: In the study Tintelnot et al. identified a microbiota-derived metabolite that has clinical implications in the treatment of pancreatic cancer. Sciomics supported the authors by a protein profiling study of tumours derived from a mouse model upon treatment with 3-IAA and Firinox.

Tintelnot et al. Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer. Nature 615, 168-174 (2023)

Article | Cycle-dependent biomarkers in endometriosis

| May 2022 | In a study by Maja Pušić et al. Cycle-dependent plasma protein biomarkers for peritoneal endometriosis were identified by our scioDiscover platform.

Pušić, M. et al. Antibody Arrays Identified Cycle-Dependent Plasma Biomarker Candidates of Peritoneal Endometriosis. J. Pers. Med. 2022, 12, 852.

Testimonials scioDiscover protein profiling

Tara Sigdel, PhD

Associate Professor, Department of Surgery, University of California San Francisco

"We collaborated with Sciomics GmbH in Germany to analyze proteomics data from blood samples of kidney transplant recipients and liver perfusates during normothermic machine perfusion. Throughout the process, Sciomics provided exceptional support, ensuring timely data delivery and valuable assistance with data analysis. Their expertise and commitment have been instrumental in advancing our research, and we are currently using their data in multiple manuscript submissions. I highly recommend Sciomics for their reliable service and expertise in proteomics."

Product: scioDiscover

Dr. Matthew Wright

Chief Scientific Officer, Kinarus Therapeutics AG, Basel, Switzerland

"We are a small biotech company without our own wet labs. Sciomics recommended a UK CRO that performed cell culture experiments for our studies. Sciomics seamlessly coordinated the transfer of the biologic materials to their facility and performed the scioCD panel to characterize cell surface markers and cytokines in cell lines treated with our small molecule drug candidates. The Sciomics data were instrumental in supporting our IP protection strategy. Their advice was very helpful and they worked with us to extract the most out of the data. We are very satisfied and highly recommend the Sciomics platform and the team."

Product: scioCD

Kyriaki Barmpa

PhD Candidate, Developmental and Cellular Biology, Luxembourg Centre for Systems Biomedicine, University of Luxembourg

"By collaborating with Sciomics, we conducted a detailed analysis of the proteome of striatum organoids, uncovering significant differences that further assisted our research. Their communication was highly efficient, and the results were delivered promptly."

Product: scioPhospho

Our protein profiling services

scioDiscover - In depth profiling on the protein level
Knowledge about protein expression levels is of utmost importance to predict toxic effects, estimate adverse effects of drug candidates and to identify new drug targets. Sciomics has a highly optimised…

scioUbi: protein profiling and ubiquitination status
Protein & ubiquitination profiling scioUbi is a high-content protein expression and ubiquitination level analysis. With scioUbi you can analyse more than 1,400 proteins in a single assay.   Features Screen…

scioPhospho: phosphoproteomics and protein profiling service
Discover protein abundance and phosphorylation analysis in one step by our high-throughput scioPhospho platform. Simultaneous detection of protein levels & phosphorylation status of > 1,500 proteins. Our scioPhospho protein phosphorylation…

scioCD - Cell Surface Marker and Cytokine Profiling
Immune response profiling Cellular composition and signalling CD-Marker Expression Profiles       Our scioCD profiling service covers 349 different proteins : up to 141 unique CD-marker molecules up to 119 cytokines and chemokines

scioCyto : Cytokine Profiling
scioCyto is a high-content analysis service for a multiplex cytokine and chemokine profiling on protein level. A great variety of samples such as plasma, tissue, cells or cell culture supernatants can be screened in a high sensitivity and reproducibility
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