Meet us at BIO-EUROPE 2021

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Partners

 

Animal models

 

 

Phenos GmbH

Contract research organisation offering services and research expertise to pharmaceutical companies and academia. PHENOS core expertise is the physiological and pathological analysis of mice and rat models. Using its long lasting experience in in-vivo models, Phenos provides its sophisticated expertise in three major areas:

  • Phenotypical analysis of genetic altered mice (e.g. knock-out animals)
  • Preclinical in-vivo evaluation of new drug compounds
  • Identification of new therapeutic strategies of approved drugs
  • Animal models for the study of kidney disease

 

Cell-Based Assay Services

 

 

Kitos biotech s.r.l.s.

Cell-Based Assay Services for Anticancer Drug Discovery Research.

The goal of Kitos is to assist customers in discovering innovative therapeutic products in an efficient, cost effective manner. ​Kitos has a well-equipped facility with cutting-edge technologies and a team of expert and dedicated scientists.

 

Antibody Specificity Assessment

 

 

Cambridge Protein Arrays Ltd.

Cambridge Protein arrays is a CRO offering analysis services based on complex human protein arrays. While the antibody arrays of Sciomics can be used to profile the content of proteins in a sample, recombinant protein arrays are especially useful for the interpretation of binding parameters of antibodies or auto-antibodies to a human proteins. Such arrays provide ultimate insights in the specificity of an antibody and information on eventual cross-binding events.

   

PEPperPRINT GmbH

Pepperprint offers standard and customized peptide microarrays with their proprietary LASER peptide printing technology which combines high spot densities with content flexibility, production speed and quality in a uniquely cost-effective manner. 
 

 

Recombinant antibodies

 

  
   

YUMAB GmbH

YUMAB provides tailored solutions for human antibody development and antibody engineering problems. YUMAB provides rapid, large-scale discovery and optimization of human monoclonal antibodies, custom libraries, antibody engineering (e.g., humanization, affinity maturation, various antibody product formats), and custom-made antibodies to difficult antigen targets. YUMAB offers fee-for-service solutions, and attractive and flexible licensing options for diagnostics and therapeutics. 

 

Instrumentation

 

 

DITABIS AG

DITABIS entwickelt und fertigt auf der Basis von OEM-Partnerschaften Medizingeräte, Laborgeräte oder Imagingsysteme für Anwendungen in den Bereichen Health Care, Life Science und In-Vitro-Diagnostik.

 

 

 

 

 Research projects

 

 

MCDS-Therapy (@MCDS-Therapy)

A Horizon 2020 funded 5-year clinical trial for the repurposing of carbamazepine for the treatment of metaphyseal chondrodysplasia, type Schmid.

> Read our press release

     

 

 

 

Networks

 

 

BIO Deutschland

As the sector association of the biotechnology industry, BIO Deutschland has set itself the objective of supporting and promoting the development of an innovative economic sector based on modern biosciences.

   

DECHEMA

DECHEMA is the expert network for chemical engineering and biotechnology in Germany. As a non-profit professional society we represent these fields in science, industry, politics and the general public. DECHEMA promotes scientific and technical exchange among experts from different disciplines, organisations and generations. We consolidate the know-how of over 5,800 individual and sustaining members.

 

BioRN

Over the past few years the Rhine-Neckar biotech region has developed into one of Germany’s strongest biotechnology clusters. The cluster is located within a radius of 30 km around the cities of Heidelberg, Mannheim, Darmstadt and Ludwigshafen. It is the most prominent and concentrated biotech cluster in Germany in the fields of personalized medicine and cancer research.

 

Technologiepark Heidelberg

Heidelberg Technology Park is a science park where major research institutes and global corporations work side by side. The synergies are manifold so that what emerges is a science-based society in which science finds scope for experimentation in industry and scientific research gains new perspectives as a result of international cooperation.

 

BioLAGO e.V.

BioLAGO is the cross-border health network for life sciences in the four-country-region of Lake Constance (Germany, Switzerland, Austria and Liechtenstein). The network links industry with science for innovations; it promotes knowledge transfer and the foundation of new firms.

 

Network Lab-on-a-Chip Technologies

Lab-on-a-Chip approaches (short: LoaC) are the combination and integration of several analytical steps of classical and new laboratory analysis on a glass, silicium or plastic chip. The goal is to achiev a high degree of automation as well as the parallelization of many analytical steps (keyword " High Content Screening").

The network focuses on innovative products, production processes and services primarily in the fields of

  • Point-of-care diagnostics systems / Biomarker development
  • Replacement of animal experiments by "organ-on-a-chip" approaches
  • cell analysis / microbiology
  • chip manufacturing

 

Our service portfolio

scioPhospho: protein profiling and phosphorylation status

scioPhospho: protein profiling and phosphorylation status

scioPhospho combines the advantages of a robust and cost-efficient protein expression profiling using scioDiscover with information on phosphorylation status. This combination provides a comprehensive overview on signalling events and pathway activity regulation. Features 1,300 highly relevant proteins are profiled in a single assay Phosphorylation status combined with protein expression levels…
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scioDiscover - Protein Profiling on expression level

scioDiscover - Protein Profiling on expression level

Knowledge about protein expression levels is of utmost importance to predict toxic effects, estimate adverse effects of drug candidates and to identify new drug targets. Sciomics has a highly optimised…
scioCD - Cell surface marker and Cytokine profiling

scioCD - Cell surface marker and Cytokine profiling

  Characterise a certain cell type?   Cell composition in a certain tissue sample?   In-depth profiling of CD-marker expression?   Increase your throughput at high sensitivity levels? You aim…
scioUbi

scioUbi

Protein & ubiquitination profiling scioUbi is a high-content protein expression and ubiquitination level analysis. With scioUbi you can analyse up to 1,000 proteins in a single assay.   Features Screen…
scioCyto : Cytokine profiling

scioCyto : Cytokine profiling

scioCyto : Cytokine profiling scioCyto is a high-content analysis service for multiplex cytokine and chemokine profiling on protein level. A great variety of samples such as plasma, tissue, cells or…

COVID-19 related activities and services

covid 19 portfolio web

News

New article | Selective elimination of immunosuppressive T cells in patients with multiple myeloma

| Feb 2021 | Scientists at Heidelberg University Hospital used our scioCD  platform to profile CD8+SLAMF7+ cell cultures:

"High throughput screening of 351 different cytokines and immune proteins in the supernatants of the T cells cultures revealed strong upregulation of IL-6, IL-8, both vital survival factors for myeloma cells, and CXCL5, a chemokine that could enhance the frequency of CD4 Treg, in the cultures containing CD8+SLAMF7+ cells. IL-2 and IL-5 were upregulated in the control cultures without CD8+SLAMF7+ T cells, highlighting a more activated state in the control group and suggestion IL-6 and IL-8 as potential effector cytokines for the suppressive CD8+SLAMF7+ T cells."

Awwad, M. H. S. et al. (2021) ‘Selective elimination of immunosuppressive T cells in patients with multiple myeloma’, Leukemia, pp. 1–14. doi: 10.1038/s41375-021-01172-x.

 

New article | Analysis of the Differential Gene and Protein Expression Profiles of Corneal Epithelial Cells Stimulated with Alternating Current Electric Fields

| Feb 2021 | Scientists at Rostock University Medical Center used our scioCD  platform to Corneal Epithelial Cells stimulated with Alternating Current Electric Fields:

"Analysis of the protein array data revealed that the treatment of cells with AC EFs altered the expression of various protein products ... revealed activation of various diverse cellular signaling pathways in which TNF, MAPK, IL17, and PI3K-Akt signaling pathways were significantly impacted ..."

B. S. Kowtharapu et. al., „Analysis of the Differential Gene and Protein Expression Profiles of Corneal Epithelial Cells Stimulated with Alternating Current Electric Fields“, Genes, Bd. 12, Nr. 2, Art. Nr. 2, Feb. 2021, doi: 10.3390/genes12020299.

 

New article | BET-Inhibitor I-BET762 and PARP-Inhibitor Talazoparib Synergy in Small Cell Lung Cancer Cells

| Dec 2020 | Scientists at University of Sassari used our scioPhospho  platform to to analyse the synergy of BET and PARP inhibition in Small Cell Lung Cancer Cells:

"Among the I-BET762-associated and combination-associated differentially expressed proteins, 150 were common to both treatment conditions. ... Ranking I-BET762-associated and combination-associated DEPs by their differential expression revealed CHEK2 and PTEN to be among the top-downregulated proteins, whose deficiencies have been associated with HR defects and increased PARPi sensitivity. "

Fiorentino, F. P. et al. (2020) ‘BET-Inhibitor I-BET762 and PARP-Inhibitor Talazoparib Synergy in Small Cell Lung Cancer Cells’, International Journal of Molecular Sciences, 21(24). doi: 10.3390/ijms21249595.

 

New article | Activated Eosinophils Exert Antitumorigenic Activities in Colorectal Cancer

| Jan 2019 | In the article, scientists at Tel Aviv University used our scioDiscover platform to analyse tumor-associated eosinophils in colorectal cancer. The full article is published in Cancer Immunology Research.

 

New article | Protection from ischemia reperfusion injury-induced inflammation and fibrosis in C5aR2-deficient mice

| June 2018 | Complement component 5a receptor 2 (C5AR2) deficient mice are protected from inflammation and fibrosis in response to ischemia reperfusion injury. Our scioPhospho platform supported scientists at the Medical School Hannover to elucidate the underlying mechanism. The data were recently published in Kidney International.

 

Testimonials

Dr. Joachim Lupberger 

Institute for Viral and Liver Disease, Inserm U1110, University of Strasbourg, LabEx HepSYS, Strasbourg, France

"Our lab is focusing on the identification of minimal-invasive biomarkers for liver disease progression. A challenge of our humanized animal models for liver disease is the low volume of blood samples available, which did not pose any problem for the analysis. I was pleased by the prompt, friendly, and uncomplicated contact and was impressed by the results and the thorough report we received. The overall quality was excellent, which made us to continue using the service of Sciomics for follow-up projects analyzing patient material."

Product: scioPhospho

 

 Prof. Dr. Andreas Weigert 

Goethe-University Frankfurt, Faculty of Medicine, Institute of Biochemistry I, Frankfurt, Germany

"We were under considerable time pressure to gain comprehensive information about cytokine/chemokine levels in a mouse model of self-resolving inflammation. To add to our misery, we had only a small number of biological replicates to run the analyses. Thankfully, the team at Sciomics were able to come to our rescue by providing a very prompt analysis, without neglecting to properly communicate the procedure, potential caveats and other details. The whole process was a very satisfying experience, rather like working with committed colleagues than with a company, and we got great data out of the project. I do happily recommend working with Sciomics for targeted proteomics analyses."

Product: scioCD

 

Tweets

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