Protein abundance and ubiquitination analysis in one step with our high-throughput scioUbi platform.
Simultaneous detection of protein levels & ubiquitination status of > 1,500 proteins.
Our scioUbi service combines comprehensive protein profiling using scioDiscover with analysis of the corresponding protein ubiquitination patterns. Covering more than 1,500 proteins, the platform provides deep insights into key regulatory pathways involved in processes such as protein degradation, signal transduction, and cellular stress responses.
scioUbi enables a fast and cost-effective in-depth analysis of protein abundance and ubiquitination from minute sample amounts — including human biospecimens, organoid models, cell cultures, and animal models. Our full-service workflow includes expert data analysis, delivering valuable insights into ubiquitin-related regulatory mechanisms and disease processes for preclinical and translational research.
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The Assay:
- Direct comparison of protein expression and ubiquitination levels in one assay
- Coverage of key signalling pathways and ubiquitin-regulated processes
- Analysis of various sample types with minimal sample amounts
- Native matrices (non-fractionated / non-depleted)
- 4 replicates for each antibody
- High reproducibility (CV < 10%)
Applications
- Post-translational modification biomarker discovery
- Analysis of ubiquitin-regulated signalling and protein degradation
- Mode-of-Action studies
- Disease mechanism screening
- Identification of novel or predicted ubiquitination events
Data Analysis is included
- Comprehensive data analysis using a basis of >12,000 data points for each sample
- Differential analysis of protein abundance and ubiquitination status
- Protein interaction network analysis
- Biological and pathway classification
