| 20.11.2013 | In an article in the current issue of Biospektrum,we compare protein levels in the blood of NOD-SCID and FVB mouse strains with complex antibody microarrays.
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| 12.12.2013 | There is a new article in the current issue of Proteomics Clinical Applications on an analysis of the blood protein profile of different B-cell lymphoma using complex antibody microarrays. 200 blood samples from patients with Diffuse Large B-cell Lymphoma (DLBCL), Follicular Lymphoma (FL), Chronic Lymphocytic Leukemia (CLL) as well as healthy controls were analysed and compared with each other. The study identified proteins with discriminating power among the different lymphoma types, as well as subgroups within each lymphoma entity.
| January 2018 | A scioDiscover protein microarray study contributed to an article in Cell Reports. In this study Gerard Ruiz-Babot et al. analysed a donor specific reprogramming of cells.
Customer testimonial Leonardo Guasti, PhD (senior author):
This has undoubtedly opened new avenues in our research. We have found the Sciomics team to be extremely helpful and efficient during the whole process, from advising the best strategy to the final interpretation of results.
| February 2018 | Researchers at Rostock University Medical Center published an article on the role of Corneal Stromal Cells on Epithelial Cell Function during Wound Healing in the International Journal of Molecular Sciences.
> Customer Testimonial Bhavani Kowtharapu:
"I am really happy with service of Sciomics. Very friendly team and really fast service and we have the results in our hand including bioinformatics analysis within 2 weeks. Thank you Sciomics team."
| June 2018 | Complement component 5a receptor 2 (C5AR2) deficient mice are protected from inflammation and fibrosis in response to ischemia reperfusion injury. Our scioPhospho platform supported scientists at the Medical School Hannover to elucidate the underlying mechanism.
Thorenz, A., Derlin, K., Schröder, C., et al. 2018 Enhanced activation of interleukin-10, heme oxygenase-1, and AKT in C5aR2-deficient mice is associated with protection from ischemia reperfusion injury–induced inflammation and fibrosis. Kidney International 94, 741–755.
| Dec 2020 | Scientists at University of Sassari used our scioPhosphoplatform to to analyse the synergy of BET and PARP inhibition in Small Cell Lung Cancer Cells:
"Among the I-BET762-associated and combination-associated differentially expressed proteins, 150 were common to both treatment conditions. ... Ranking I-BET762-associated and combination-associated DEPs by their differential expression revealed CHEK2 and PTEN to be among the top-downregulated proteins, whose deficiencies have been associated with HR defects and increased PARPi sensitivity. "
Fiorentino, F. P. et al. (2020) ‘BET-Inhibitor I-BET762 and PARP-Inhibitor Talazop. Synergy in Small Cell Lung Cancer Cells’, International Journal of Molecular Sciences, 21(24). doi: 10.3390/ijms21249595.
| Feb 2021 | Scientists at Rostock University Medical Center used our scioCDplatform to Corneal Epithelial Cells stimulated with Alternating Current Electric Fields:
"Analysis of the protein array data revealed that the treatment of cells with AC EFs altered the expression of various protein products ... revealed activation of various diverse cellular signaling pathways in which TNF, MAPK, IL17, and PI3K-Akt signaling pathways were significantly impacted ..."
B. S. Kowtharapu et. al., „Analysis of the Differential Gene and Protein Expression Profiles of Corneal Epithelial Cells Stimulated with Alternating Current Electric Fields“, Genes, Bd. 12, Nr. 2, Art. Nr. 2, Feb. 2021, doi: 10.3390/genes12020299.
| Feb 2021 | Scientists at Heidelberg University Hospital used our scioCD platform to profile CD8+SLAMF7+ cell cultures:
"High throughput screening of 351 different cytokines and immune proteins in the supernatants of the T cells cultures revealed strong upregulation of IL-6, IL-8, both vital survival factors for myeloma cells, and CXCL5, a chemokine that could enhance the frequency of CD4 Treg, in the cultures containing CD8+SLAMF7+ cells. IL-2 and IL-5 were upregulated in the control cultures without CD8+SLAMF7+ T cells, highlighting a more activated state in the control group and suggestion IL-6 and IL-8 as potential effector cytokines for the suppressive CD8+SLAMF7+ T cells."
Awwad, M. H. S. et al. ‘Selective elimination of immunosuppressive T cells in patients with multiple myeloma’, Leukemia 35 2602-2615 (2021)
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