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| October 2022 | Dapr. protects against induced kidney toxicity and anemia by preventing protein phosphorylation changes, preserving microcirculation, and maintaining hemoglobin levels.
Sciomics contributed to this study by analyzing mouse kidney samples using the scioPhospho proteomic assay.
| June 2018 | Complement component 5a receptor 2 (C5AR2) deficient mice are protected from inflammation and fibrosis in response to ischemia reperfusion injury. Our scioPhospho platform supported scientists at the Medical School Hannover to elucidate the underlying mechanism.
Thorenz, A., Derlin, K., Schröder, C., et al. 2018 Enhanced activation of interleukin-10, heme oxygenase-1, and AKT in C5aR2-deficient mice is associated with protection from ischemia reperfusion injury–induced inflammation and fibrosis. Kidney International 94, 741–755.
Dr. Bettina Grötsch
Department of Medicine 3 - Rheumatology and Immunology, University Clinics Erlangen, Erlangen, Germany
"Our lab is working with human osteoclast that were isolated and differentiated from human peripheral blood. Therefore, we were quite limited in cell numbers and protein content for our planned Phosphoprotein analyses. Nonetheless, Sciomics and especially Camille Lowy helped us a lot to test and improve our protein isolation techniques to achieve some interesting phosphoproteome data in human osteoclasts. We were really impressed by the detailed data report and their willingness to discuss and reanalyze the data repeatedly until we got the best results out of our measurements. Even several month after their first report, we could ask for help and suggestions with an immediate reply. The phosphoproteome analyses completed our preliminary project data and are now published in Frontiers Immunology. Altogether, we were very happy with the service of Sciomics and special thanks to Camille Lowy and Christoph Schröder who guided us through the whole process."
Product: scioPhospho
Publication: Grötsch B. et al. 2022 Front. Immunol. 13:958974
Dr. Leonardo Guasti
Centre for Endocrinology, William Harvey Research Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
"We were satisfied with the service provided by Sciomics back in 2017, so when it came to study a newly discovered secreted protein, for which little biology is known, we decided to engage again with them. Indeed, the phosphorylation and protein expression level data provided by Sciomics was of great help in assessing modulation of pathways initiated by adrenal cortex cells treated with this protein. Crucially, the Sciomics team actively engaged with us during both the planning of the experiments and subsequently in data analysis. This comprehensive data set has truly put us in the right path to dig into the role of a newly discovered protein in adrenocortical pathobiology."
Product: scioPhospho
