Latest Scientific Publications

Article | IVF Stimulation Alters Endometrial Protein Profiles During Implantation

| May 2026 | Significant alterations in endometrial protein expression during ovarian stimulation cycles in women with poor ovarian response suggest potential biomarkers linked to implantation and endometrial receptivity. Sciomics supported the study with protein profiling of human endometrial biopsy tissue usingthe scioDiscover affinity proteomics platform.

Abdulkhalikova et al., Distinct endometrial protein profiles in spontaneous and stimulated cycles in women with poor ovarian response: A prospective case-crossover clinical trial. PLoS One. 2026;21(5):e0338812.  

Article | Stromal Chemokine Rewiring in B Cell Lymphoma

| March 2026 | Inflammatory reprogramming of stromal chemokine networks drives tissue disorganisation and disease progression in nodal B cell lymphoma. Sciomics supported the study with secretome profiling of human iFRC supernatant samples using the scioCD affinity proteomics platform.

Czernilofsky et al., Reprogramming of stroma-derived chemokine networks drives the loss of tissue organization in nodal B cell lymphoma. Nature Cancer. 2026;7:538-552.  

Article | Fimepinostat Targets HDAC2 to Suppress Schwannoma Growth

| March 2026 | The HDAC inhibitor fimepinostat effectively induces apoptosis and suppresses tumor cell proliferation, highlighting its potential as a therapeutic strategy for schwannoma.
Sciomics supported the study with proteomic profiling and post-translational modification analysis of human cell samples.

Nagel et al., Fimepinostat Promotes Apoptosis and Decreases Cytokine Secretion in NF2-Related Human Schwannoma Cells. Int. J. Mol. Sci. 2026, 27, 2636  

Article | GPRC5D Loss Promotes Myeloma Resistance to Immunotherapy

| March 2026 | GPRC5D loss promotes immunotherapy resistance and aggressive multiple myeloma growth, supporting early monitoring and dual-targeted treatment strategies. Sciomics supported the study with cytokine profiling of human OPM-2 supernatant samples using the scioCyto affinity proteomics platform.

Munawar et al., Loss of GPRC5D enhances the proliferative capacity and competitive fitness of myeloma upon anti-GPRC5D immunotherapy. Leukemia. Published online March 31, 2026.  

Article | Parkinson’s Striatum Organoids Show Increased Inflammation Hallmarks

| February 2026 | Patient-derived striatum organoids carrying the LRRK2-G2019S mutation reveal early Parkinson’s Disease features, including neuroinflammation and altered signalling. Sciomics supported the study by analysing patient-derived striatum organoids using the scioDiscover proteomic microarray.

Barmpa et al., Parkinson’s Disease Patient-Specific Striatum Organoids Show Hallmarks of Increased Inflammation. Mov Disord. (2026), published online February 11, 2026  

Proteomics Research Blog

Article | Predicting a severe Covid-19 disease

| April 2023 | New Article: In a protein biomarker development project initiated by Sciomics, we have identified protein biomarker panels predicting development of a severe Covid.19  disease.

Hufnagel K., Fathi A. et al. Discovery and systematic assessment of early biomarkers that predict progression to severe COVID-19 disease. Communications Medicine 3,51 (2023)

Article | Prevention of anemia and peritubular capillary loss

| October 2022 | Dapr. protects against induced kidney toxicity and anemia by preventing protein phosphorylation changes, preserving microcirculation, and maintaining hemoglobin levels.
Sciomics contributed to this study by analyzing mouse kidney samples using the scioPhospho proteomic assay.

Labes, R., Brinkmann, L. , Kulow, V.A., et al. Dapr. prevents cyclosp.-A-mediated anemia and peritubular capillary loss. Kidney Int. 2022;102(4):750-765.

Article | Microbiota influences chemotherapy in pancreatic cancer

| February 2023 | New Article: In the study Tintelnot et al. identified a microbiota-derived metabolite that has clinical implications in the treatment of pancreatic cancer. Sciomics supported the authors by a protein profiling study of tumours derived from a mouse model upon treatment with 3-IAA and Firinox.

Tintelnot et al. Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer. Nature 615, 168-174 (2023)

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