Our scioDiscover service enables high-content, immuno-based analysis of various biological samples, providing a comprehensive overview of proteomic changes. The service covers key pathways in numerous diseases such as cancer, neurological disorders and organ failure. The technology has been successfully applied in a variety of biomedical studies and for the discovery of new biomarker signatures. Within the analysis, more than 1,400 proteins are analyzed in parallel. The scioDiscover protein array-based service enables fast and targeted research while providing a broad overview of potential protein-level changes in your samples.
Applications |
Sample Types & Requirements |
Advantages |
Service includes |
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Signaling pathway profiling Immune system activation marker profiling Transcription factor analysis Cancer pathway screening Cell surface marker profiling Profiling of apoptotic processes/ apoptosis pathway analysis Disease mechanism profiling Pathway activation in stem cells Analysis of organ damage/failure models Response of cells and tissue models to oxidative stress analysis Profiling proteomic changes for various cell culture conditions Molecular initiate event analysis Molecular initiate event analysis Compound mode-of-action analysis Prediction markers for toxicological effects Biomarker Discovery Drug Target Discovery CD cell surface molecule expression in immune cells |
plasma/serum - 5 µl* tissue - 1 mg* (fresh frozen) cells - 100,000* cerebrospinal fluid (CSF) - 30 µl* cell culture supernatant - 100µl* other sample types upon request
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high-content more than 1,400 proteins analyzed broad coverage of
minimal sample requirements native matrixes (non-fractionated/non-depleted) sensitivity as ELISA or better fully immuno-based assay reliable dual-colour study design high reproducibility (CV < 10%)
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sample preparation protein extraction protein concentration measurements protein quality control sample labelling sample purification sample incubation on arrays raw data acquisition data normalisation data analysis statistical analysis comprehensive study report
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* Minimum quantity. These values may vary depending on the sample type, study design, storage conditions. and additional parameters.
Target Coverage - GO Annotations
Biological Process |
Cellular Components |
Protein Classes |
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| cellular process (GO:0009987) | 438 | cell part (GO:0044464) | 172 | signaling molecule (PC00207) | 122 |
| metabolic process (GO:0008152) | 410 | organelle (GO:0043226) | 97 | receptor (PC00197) | 113 |
| response to stimulus (GO:0050896) | 228 | extracellular region (GO:0005576) | 60 | nucleic acid binding (PC00171) | 109 |
| biological regulation (GO:0065007) | 220 | membrane (GO:0016020) | 59 | hydrolase (PC00121) | 77 |
| developmental process (GO:0032502) | 172 | macromolecular complex (GO:0032991) | 47 | transcription factor (PC00218) | 71 |
| immune system process (GO:0002376) | 145 | extracellular matrix (GO:0031012) | 28 | enzyme modulator (PC00095) | 67 |
| localization (GO:0051179) | 116 | cell junction (GO:0030054) | 3 | cell adhesion molecule (PC00069) | 62 |
| multicellular organismal process (GO:0032501) | 72 | synapse (GO:0045202) | 2 | defense/immunity protein (PC00090) | 52 |
| apoptotic process (GO:0006915) | 67 | cytoskeletal protein (PC00085) | 40 | ||
| cellular component organization or biogenesis (GO:0071840) | 65 | oxidoreductase (PC00176) | 31 | ||
| biological adhesion (GO:0022610) | 60 | kinase (PC00137) | 31 | ||
| reproduction (GO:0000003) | 26 | transporter (PC00227) | 27 | ||
| locomotion (GO:0040011) | 4 | transfer/carrier protein (PC00219) | 25 | ||
| calcium-binding protein (PC00060) | 20 | ||||
| phosphatase (PC00181) | 20 | ||||
| structural protein (PC00211) | 18 | ||||
| extracellular matrix protein (PC00102) | 17 | ||||
| cell junction protein (PC00070) | 17 | ||||
| membrane traffic protein (PC00150) | 14 | ||||
Please note: GO annotation terms may overlap
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Reference customers:
Prof. Dr. Faikah Güler, Medical School Hanover, Germany
Julian Kamhieh-Milz, Charite, Berlin, Germany
Case Study - Acute Kidney Injury
