To enable personalized medicine and diagnostic research, we need techniques to discover and validate novel and more accurate biomarkers. Our immuno-based discovery service for protein biomarkers utilizes complex antibody microarrays, spanning crucial pathway proteins for multiple diseases and secreted proteins. Our platform has been successfully applied in a variety of biomedical research studies. The platform's potential is highlighted by the successful discovery of four innovative biomarker signatures.
Our fully immuno-based workflow eliminates the need for major platform alterations, reducing attrition rates for biomarker candidates during further development. Over a decade of experience in discovering and validating protein biomarkers makes Sciomics an excellent partner for your research.
Biomarker Discovery for
- Diagnosis
- Differential Diagnosis
- Prognosis
- Drug Response Prediction and Therapy Stratification
- Companion diagnostics
Service Features
- Design of a suitable study layout
- Protein extraction & purification
- Protein quantification
- Protein labeling using high-performance fluorescent dyes
- Fully automated array incubation and handling
- Array scanning, data acquisition and spot recognition
- Customized data analysis to fit your needs
- Tailored study report
Key Advantages
- High sensitivity (comparable to or better than ELISA)
- High reproducibility (CV < 10%)
- Fast turnaround time, as little as two weeks*
- Ability to analyze various sample types
- Serum or plasma
- fresh-frozen tissue samples
- Cell culture samples
- Cerebrospinal fluid (CSF)
- Minimum sample consumption, for instance**
- Plasma sample: 5µl
- Tissue: 1mg (fresh-frozen)
- Cells: 100,000
- CSF: 5µl
- Investigation of human and murine samples***
- No need for laborious depletion or fractionation of your samples
- Verification and clinical validation without major platform change
- Parallel verification of multiple biomarker candidates using Custom Antibody Arrays
Overview
Scio-Discover Array
Content Quality
Assurance Contact
us
Reference Customers:Prof. Dr. Faikah Güler, Medical School Hanover, Germany Julian Kamhieh-Milz, Charite, Berlin, Germany |
Case Studies: |
* depending on study design and sample size
**Minimum quantity. These values may vary depending on the sample type, study design, storage conditions. and additional parameters.
*** The antibody array is designed specifically to target human proteins. Because of the high sequence homology shared by the majority of proteins, this approach has frequently been used to study murine, rat, and ovine models effectively. [Thorenz A. et al. (2018), Peiro J. et al. (2018), Reichman H. et al. (2019), Raquel F. et al. (2020)].
