Sciomics‘ Impact on Proteomic Research

New Article | Endothelial Notch1 signaling in white adipose tissue promotes cancer cachexia

| September 2023 | New Article: Endothelial Notch1 signaling in white adipose tissue promotes cancer cachexia. Sciomics supported this study by scioCyto serum analysis in a mouse cancer model.

Taylor, J., Uhl, L., Moll, I. et al. Endothelial Notch1 signaling in white adipose tissue promotes cancer cachexia. Nat Cancer 4, 1544–1560 (2023)

Overview of Scientific Publications & Patents

Please find below selected patents and scientific publications on our antibody microarray platform or its application in biomedical studies published in peer-reviewed journals. The articles were either published by our collaborators or customers or by Sciomics team. You will also find information on presentations at scientific conferences. 

 

Selected Scientific Publications by our Customers and Partners

2024

  • Lieder, H. R., Paket, U., Skyschally, A., Rink, A. D., Baars, T., Neuhäuser, M., Kleinbongard, P., Heusch, G.. (2024)
    Vago-splenic signal transduction of cardioprotection in humans, European Heart Journal, 2024;, ehae250, https://doi.org/10.1093/eurheartj/ehae250
  • Michel, M., Renaud, D., Schmidt, R., Einkemmer, M., Laser, L.V., Michel, E., Dubowy, K.O., Karall, D., Laser, K.T., Scholl-Bürgi, S. (2024)
    Altered Serum Proteins Suggest Inflammation, Fibrogenesis and Angiogenesis in Adult Patients with a Fontan Circulation. Int. J. Mol. Sci. 25, 5416.
    https://doi.org/10.3390/ijms25105416
  • Ringelhan, M., Schuehle, S., van de Klundert, M., Kotsiliti, E., Plissonnier, M.-L., Faure-Dupuy, S., Riedl, T., Lange, S., Wisskirchen, K., Thiele, F., Cheng, C.-C., Yuan, D., Leone, V., Schmidt, R., Hünergard, J., Geisler, F., Unger, K., Algül, H., Schmid, R. M., Rad, R., Wedemeyer, H., Levrero, M., Protzer, U.,Heikenwalder, M. (2024)
    HBV-related HCC development in mice is STAT3 dependent and indicates an oncogenic effect of HBx, JHEP Reports, 101128.
    https://doi.org/10.1016/j.jhepr.2024.101128.
  • Sigdel, T.K., Sur, S., Boada, P. et al. (2024)
    Proteome Analysis for Inflammation Related to Acute and Convalescent Infection. Inflammation 47, 346–362. https://doi.org/10.1007/s10753-023-01913-3

2023

  • Fiedler MK, Drechsel J, Schmidt R, Luppa PB, Bach NC, Sieber SA. (2023)
    Rapid Diagnostic Platform for Personalized Vitamin B6 Detection in Erythrocytes via PLP Cofactor Mimics.
    ACS Chem Biol. Jul 5. doi: 10.1021/acschembio.3c00279. Epub ahead of print.
  • Galadima, M.; Kotova, I.; Schmidt, R.; Pastor, J.; Schröder, C.; Rodríguez-Gil, J.E.; del Alamo, M.M.R. (2023)
    Canine Mammary Neoplasia Induces Variations in the Peripheral Blood Levels of CD20, CD45RA, and CD99. 
    Int. J. Mol. Sci.24, 9222. https://doi.org/10.3390/ijms24119222
  • Vid Janša, Maja Pušić Novak, Helena Ban Frangež, Tea Lanišnik Rižner (2023)
    TGFBI as a candidate biomarker for non-invasive diagnosis of early-stage endometriosis, Human Reproduction, Volume 38, Issue 7, July 2023, Pages 1284–1296, https://doi.org/10.1093/humrep/dead091
  • Kundu, S., Nunes, L., Adler, J. et al. (2023)
    Recurring EPHB1 mutations in human cancers alter receptor signalling and compartmentalisation of colorectal cancer cells.
    Cell Commun Signal 21, 354 (2023). https://doi.org/10.1186/s12964-023-01378-9
  • Romano A, Rižner TL, Werner HMJ, Semczuk A, Lowy C, Schröder C, Griesbeck A, Adamski J, Fishman D and Tokarz J (2023)
    Endometrial cancer diagnostic and prognostic algorithms based on proteomics, metabolomics, and clinical data: a systematic review. Front. Oncol. 13:1120178. doi: 10.3389/fonc.2023.1120178
  • Taylor, J., Uhl, L., Moll, I. et al. (2023)
    Endothelial Notch1 signaling in white adipose tissue promotes cancer cachexia. Nat Cancer 4, 1544–1560 (2023). https://doi.org/10.1038/s43018-023-00622-y
  • Tintelnot, J., Xu, Y., Lesker, T.R. et al. (2023)
    Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer. Nature 615, 168–174 (2023). https://doi.org/10.1038/s41586-023-05728-y
  • Wiedmann, L., De Angelis Rigotti, F., Vaquero-Siguero, N., Donato, E., Espinet, E., Moll, I., Alsina-Sanchis, E., Bohnenberger, H., Fernandez-Florido, E., Mülfarth, R., Vacca, M., Gerwing, J., Conradi, L. C., Ströbel, P., Trumpp, A., Mogler, C., Fischer, A., & Rodriguez-Vita, J. (2023) 
    HAPLN1 potentiates peritoneal metastasis in pancreatic cancer. 
    Nature communications14(1), 2353. https://doi.org/10.1038/s41467-023-38064-w

2022

  • Abdulkhalikova D, Sustarsic A, Vrtačnik Bokal E, Jancar N, Jensterle M and Burnik Papler T. (2022)
    The Lifestyle Modifications and Endometrial Proteome Changes of Women With Polycystic Ovary Syndrome and Obesity.
    Front Endocrinol. 13:888460. doi:10.3389/fendo.2022.888460.
  • Franz S, Ertel A, Engel KM, Simon JC, Saalbach A. (2022)
    Overexpression of S100A9 in obesity impairs macrophage differentiation via TLR4-NFkB-signaling worsening inflammation and wound healing.
    Theranostics. 12(4):1659-1682. doi:10.7150/thno.67174
  • Groetsch B., Schachtschabel E., Tripal P., Schmid B., Smith A., Schett G.A. and Bozec A. (2022)
    Inflammatory activation of FcgR and IFNgR pathways co-influence the differentiation and activity of osteoclasts.
    Front. Immunol. 13:958974. doi:10.3389/fimmu.2022.958974
  • Labes R, Brinkmann L, Kulow VA, Roegner K, Mathia S, Balcerek B, Persson PB, Rosenberger C and Fähling M.  (2022)
    Daprodustat prevents cyclosporine-A mediated anemia and peritubular capillary loss.
    Kidney Int. S0085-2538(22)00375-1. doi:10.1016/j.kint.2022.04.025
  • Marino, D., Pizzi, M., Kotova, I., Schmidt, R., Schröder, C., Guzzardo, V., Talli, I., Peroni, E., Finotto, S., Scapinello, G., Dei Tos, A.P., Piazza, F., Trentin, L., Zagonel, V. and Piovan, E., (2022)
    High ETV6 Levels Support Aggressive B Lymphoma Cell Survival and Predict Poor Outcome in Diffuse Large B-Cell Lymphoma Patients.
    Cancers 14. https://doi.org/10.3390/cancers14020338
  • Pušić M, Klančič T, Knific T, Vogler A, Schmidt R, Schröder C and Lanišnik Rižner T. (2022)
    Antibody Arrays Identified Cycle-Dependent Plasma Biomarker Candidates of Peritoneal Endometriosis.
    J Pers Med. 12(6):852. doi: 10.3390/jpm12060852.
  • Watson, C.N., Begum, G., Ashman, E., Thorn, D., Yakoub, K.M., Hariri, M.A., Nehme, A., Mondello, S., Kobeissy, F., Belli, A. and Di Pietro, V.,  (2022)
    Co-Expression Analysis of microRNAs and Proteins in Brain of Alzheimer’s Disease Patients.
    Cells 11, 163. https://doi.org/10.3390/cells11010163

2021

  • Awwad, M.H.S., Mahmoud, A., Bruns, H., Echchannaoui, H., Kriegsmann, K., Lutz, R., Raab, M.S., Bertsch, U., Munder, M., Jauch, A., Weisel, K., Maier, B., Weinhold, N., Salwender, H.J., Eckstein, V., Hänel, M., Fenk, R., Dürig, J., Brors, B., Benner, A., Müller-Tidow, C., Goldschmidt, H., Hundemer, M., (2021)
    Selective elimination of immunosuppressive T cells in patients with multiple myeloma.
    Leukemia 35, 2602–2615. https://doi.org/10.1038/s41375-021-01172-x
  • Fomitcheva-Khartchenko, A., Rapsomaniki, M.A., Sobottka, B., Schraml, P., Kaigala, G.V., (2021) 
    Spatial protein heterogeneity analysis in frozen tissues to evaluate tumor heterogeneity.
    PLOS ONE 16, e0259332. https://doi.org/10.1371/journal.pone.0259332
  • Janša, V., Klančič, T., Pušić, M., Klein, M., Vrtačnik Bokal, E., Ban Frangež, H., Rižner, T.L., (2021) 
    Proteomic analysis of peritoneal fluid identified COMP and TGFBI as new candidate biomarkers for endometriosis.
    Sci Rep 11, 20870. https://doi.org/10.1038/s41598-021-00299-2
  • Jarazo, J., Barmpa, K., Modamio, J., Saraiva, C., Sabaté‐Soler, S., Rosety, I., Griesbeck, A., Skwirblies, F., Zaffaroni, G., Smits, L.M., Su, J., Arias‐Fuenzalida, J., Walter, J., Gomez‐Giro, G., Monzel, A.S., Qing, X., Vitali, A., Cruciani, G., Boussaad, I., Brunelli, F., Jäger, C., Rakovic, A., Li, W., Yuan, L., Berger, E., Arena, G., Bolognin, S., Schmidt, R., Schröder, C., Antony, P.M.A., Klein, C., Krüger, R., Seibler, P., Schwamborn, J.C., (2021)
    Parkinson’s Disease Phenotypes in Patient Neuronal Cultures and Brain Organoids Improved by 2‐Hydroxypropyl‐β‐CyclodextrinTreatment.
    Mov Disord mds.28810. https://doi.org/10.1002/mds.28810
  • Kowtharapu, B.S., Damaraju, J., Singh, N.K., Ziebart, J., Bader, R., Koczan, D., Stachs, O., (2021)
    Analysis of the Differential Gene and Protein Expression Profiles of Corneal Epithelial Cells Stimulated with Alternating Current Electric Fields.
    Genes 12, 299. https://doi.org/10.3390/genes12020299
  • Lange, C., Weber, A.M., Schmidt, R., Schroeder, C., Strowitzki, T., Germeyer, A., (2021)
    Changes in protein expression due to metformin treatment and hyperinsulinemia in a human endometrial cancer cell line.
    PLOS ONE 16, e0248103. https://doi.org/10.1371/journal.pone.0248103

2020

  • Boberg, E., Kadri, N., Winterling, J., Davies, L.C., Björklund, A., Msghina, M., Iacobaeus, E., Le Blanc, K., (2020) 
    Mental fatigue after allogeneic hematopoietic stem cell transplantation is associated with cognitive dysfunction, but not central nervous system inflammation.
    Haematologica 105, e310–e314. https://doi.org/10.3324/haematol.2019.225326
  • Fernando, R., Wardelmann, K., Deubel, S., Kehm, R., Jung, T., Mariotti, M., Vasilaki, A., Gladyshev, V.N., Kleinridders, A., Grune, T., Castro, J.P., (2020)
    Low steady-state oxidative stress inhibits adipogenesis by altering mitochondrial dynamics and decreasing cellular respiration.
    Redox Biology 32, 101507. https://doi.org/10.1016/j.redox.2020.101507
  • Fiorentino, F.P., Marchesi, I., Schröder, C., Schmidt, R., Yokota, J., Bagella, L., (2020)
    BET-Inhibitor I-BET762 and PARP-Inhibitor Talazoparib Synergy in Small Cell Lung Cancer Cells.
    Int J Mol Sci 21. https://doi.org/10.3390/ijms21249595
  • Yin, Y., Shelke, G.V., Lässer, C., Brismar, H., Lötvall, J., (2020)
    Extracellular vesicles from mast cells induce mesenchymal transition in airway epithelial cells.
    Respiratory Research 21, 101. https://doi.org/10.1186/s12931-020-01346-8

2019 and older

  • Fultang, L., Gamble, L.D., Gneo, L., Berry, A.M., Egan, S.A., De Bie, F., Yogev, O., Eden, G.L., Booth, S., Brownhill, S., Vardon, A., McConville, C.M., Cheng, P.N., Norris, M.D., Etchevers, H.C., Murray, J., Ziegler, D.S., Chesler, L., Schmidt, R., Burchill, S.A., Haber, M., De Santo, C., Mussai, F., (2019)
    Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma.
    Cancer Res 79, 611–624. https://doi.org/10.1158/0008-5472.CAN-18-2139
  • Reichman, H., Itan, M., Rozenberg, P., Yarmolovski, T., Brazowski, E., Varol, C., Gluck, N., Shapira, S., Arber, N., Qimron, U., Karo-Atar, D., Lee, J.J., Munitz, A., (2019)
    Activated Eosinophils Exert Antitumorigenic Activities in Colorectal Cancer.
    Cancer Immunol Res 7, 388–400. https://doi.org/10.1158/2326-6066.CIR-18-0494
  • Kowtharapu, B.S., Murín, R., Jünemann, A.G.M., Stachs, O., (2018)
    Role of Corneal Stromal Cells on Epithelial Cell Function during Wound Healing.
    International Journal of Molecular Sciences 19, 464. https://doi.org/10.3390/ijms19020464
  • Peiro, J.L., Oria, M., Aydin, E., Joshi, R., Cabanas, N., Schmidt, R., Schroeder, C., Marotta, M., Varisco, B.M., (2018)
    Proteomic profiling of tracheal fluid in an ovine model of congenital diaphragmatic hernia and fetal tracheal occlusion.
    Am J Physiol Lung Cell Mol Physiol 315, L1028–L1041. https://doi.org/10.1152/ajplung.00148.2018
  • Thorenz, A., Derlin, K., Schröder, C., Dressler, L., Vijayan, V., Pradhan, P., Immenschuh, S., Jörns, A., Echtermeyer, F., Herzog, C., Chen, R., Rong, S., Bräsen, J.H., Kooten, C. van, Kirsch, T., Klemann, C., Meier, M., Klos, A., Haller, H., Hensen, B., Gueler, F., (2018)
    Enhanced activation of interleukin-10, heme oxygenase-1, and AKT in C5aR2-deficient mice is associated with protection from ischemia reperfusion injury–induced inflammation and fibrosis.
    Kidney International 94, 741–755. https://doi.org/10.1016/j.kint.2018.04.005
  • Hamidi, Z., Tejero, E., Schmidt, R., Tucker, R., Pedro, A., (2017)
    Identification of potential blood-derived extracellular vesicles biomarkers to diagnose and predict distant metastases in ER+ breast cancer patients.
    bioRxiv 202291. https://doi.org/10.1101/202291
  • Sass, F.A., Schmidt‐Bleek, K., Ellinghaus, A., Filter, S., Rose, A., Preininger, B., Reinke, S., Geissler, S., Volk, H.-D., Duda, G.N., Dienelt, A., (2017) 
    CD31+ Cells From Peripheral Blood Facilitate Bone Regeneration in Biologically Impaired Conditions Through Combined Effects on Immunomodulation and Angiogenesis.
    Journal of Bone and Mineral Research 32, 902–912. https://doi.org/10.1002/jbmr.3062
  • Bakdash, G., Buschow, S.I., Gorris, M.A.J., Halilovic, A., Hato, S.V., Sköld, A.E., Schreibelt, G., Sittig, S.P., Torensma, R., Duiveman-de Boer, T., Schröder, C., Smits, E.L., Figdor, C.G., de Vries, I.J.M., (2016)
    Expansion of a BDCA1+CD14+ Myeloid Cell Population in Melanoma Patients May Attenuate the Efficacy of Dendritic Cell Vaccines.
    Cancer Res 76, 4332–4346. https://doi.org/10.1158/0008-5472.CAN-15-1695

 

Selected Scientific Publications by the Sciomics Team 

  • Fiedler MK, Drechsel J, Schmidt R, Luppa PB, Bach NC, Sieber SA. (2023)
    Rapid Diagnostic Platform for Personalized Vitamin B6 Detection in Erythrocytes via PLP Cofactor Mimics.
    ACS Chem Biol. Jul 5. doi: 10.1021/acschembio.3c00279. Epub ahead of print.
  • Galadima, M.; Kotova, I.; Schmidt, R.; Pastor, J.; Schröder, C.; Rodríguez-Gil, J.E.; del Alamo, M.M.R. (2023)
    Canine Mammary Neoplasia Induces Variations in the Peripheral Blood Levels of CD20, CD45RA, and CD99. 
    Int. J. Mol. Sci.24, 9222. https://doi.org/10.3390/ijms24119222
  • Hufnagel, K., Fathi, A., Stroh, N., Klein, M., Skwirblies, F., Girgis, R., Dahlke, C., Hoheisel, J. D., Lowy, C., Schmidt, R., Griesbeck, A., Merle, U., Addo, M. M., & Schröder, C. (2023)
    Discovery and systematic assessment of early biomarkers that predict progression to severe COVID-19 disease. 
    Communications medicine, 3(1), 51. https://doi.org/10.1038/s43856-023-00283-z
  • Marino, D., Pizzi, M., Kotova, I., Schmidt, R., Schröder, C., Guzzardo, V., Talli, I., Peroni, E., Finotto, S., Scapinello, G., Dei Tos, A.P., Piazza, F., Trentin, L., Zagonel, V., Piovan, E. (2022)
    High ETV6 Levels Support Aggressive B Lymphoma Cell Survival and Predict Poor Outcome in Diffuse Large B-Cell Lymphoma Patients.
    Cancers 14. https://doi.org/10.3390/cancers14020338
  • Jarazo, J., Barmpa, K., Modamio, J., Saraiva, C., Sabaté‐Soler, S., Rosety, I., Griesbeck, A., Skwirblies, F., Zaffaroni, G., Smits, L.M., Su, J., Arias‐Fuenzalida, J., Walter, J., Gomez‐Giro, G., Monzel, A.S., Qing, X., Vitali, A., Cruciani, G., Boussaad, I., Brunelli, F., Jäger, C., Rakovic, A., Li, W., Yuan, L., Berger, E., Arena, G., Bolognin, S., Schmidt, R., Schröder, C., Antony, P.M.A., Klein, C., Krüger, R., Seibler, P., Schwamborn, J.C. (2022) 
    Parkinson’s Disease Phenotypes in Patient Neuronal Cultures and Brain Organoids Improved by 2‐Hydroxypropyl‐β‐CyclodextrinTreatment.
    Mov Disord mds.28810. https://doi.org/10.1002/mds.28810
  • Pušić M, Klančič T, Knific T, Vogler A, Schmidt R, Schröder C, Lanišnik Rižner T. (2022)
    Antibody Arrays Identified Cycle-Dependent Plasma Biomarker Candidates of Peritoneal Endometriosis.
    J Pers Med. 12(6):852. doi: 10.3390/jpm12060852.
  • Janša, V., Klančič, T., Pušić, M., Klein, M., Vrtačnik Bokal, E., Ban Frangež, H., Rižner, T.L. (2021) 
    Proteomic analysis of peritoneal fluid identified COMP and TGFBI as new candidate biomarkers for endometriosis.
    Sci Rep 11, 20870. https://doi.org/10.1038/s41598-021-00299-2
  • Lange, C., Weber, A.M., Schmidt, R., Schroeder, C., Strowitzki, T., Germeyer, A. (2021)
    Changes in protein expression due to metformin treatment and hyperinsulinemia in a human endometrial cancer cell line.
    PLOS ONE 16, e0248103. https://doi.org/10.1371/journal.pone.0248103
  • Fiorentino, F.P., Marchesi, I., Schröder, C., Schmidt, R., Yokota, J., Bagella, L. (2020) 
    BET-Inhibitor I-BET762 and PARP-Inhibitor Talazoparib Synergy in Small Cell Lung Cancer Cells.
    International Journal of Molecular Sciences 21, 9595. https://doi.org/10.3390/ijms21249595
  • Fultang, L., Gamble, L.D., Gneo, L., Berry, A.M., Egan, S.A., Bie, F.D., Yogev, O., Eden, G.L., Booth, S., Brownhill, S., Vardon, A., McConville, C.M., Cheng, P.N., Norris, M.D., Etchevers, H.C., Murray, J., Ziegler, D.S., Chesler, L., Schmidt, R., Burchill, S.A., Haber, M., Santo, C.D., Mussai, F. (2019) 
    Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma.
    Cancer Res 79, 611–624. https://doi.org/10.1158/0008-5472.CAN-18-2139
  • Thorenz, A., Derlin, K., Schröder, C., Dressler, L., Vijayan, V., Pradhan, P., Immenschuh, S., Jörns, A., Echtermeyer, F., Herzog, C., Chen, R., Rong, S., Bräsen, J.H., Kooten, C. van, Kirsch, T., Klemann, C., Meier, M., Klos, A., Haller, H., Hensen, B., Gueler, F. (2018) 
    Enhanced activation of interleukin-10, heme oxygenase-1, and AKT in C5aR2-deficient mice is associated with protection from ischemia reperfusion injury–induced inflammation and fibrosis.
    Kidney International 94, 741–755. https://doi.org/10.1016/j.kint.2018.04.005
  • Peiro, J.L., Oria, M., Aydin, E., Joshi, R., Cabanas, N., Schmidt, R., Schroeder, C., Marotta, M., Varisco, B.M. (2018) 
    Proteomic profiling of tracheal fluid in an ovine model of congenital diaphragmatic hernia and fetal tracheal occlusion.
    American Journal of Physiology-Lung Cellular and Molecular Physiology 315, L1028–L1041. https://doi.org/10.1152/ajplung.00148.2018
  • Bakdash, G., Buschow, S.I., Gorris, M.A.J., Halilovic, A., Hato, S.V., Sköld, A.E., Schreibelt, G., Sittig, S.P., Torensma, R., Boer, T.D., Schröder, C., Smits, E.L., Figdor, C.G., de Vries, I.J.M. (2016)
    Expansion of a BDCA1+CD14+ Myeloid Cell Population in Melanoma Patients May Attenuate the Efficacy of Dendritic Cell Vaccines.
    Cancer Res 76, 4332–4346. https://doi.org/10.1158/0008-5472.CAN-15-1695
  • Kibat, J., Schirrmann, T., Knape, M.J., Helmsing, S., Meier, D., Hust, M., Schröder, C., Bertinetti, D., Winter, G., Pardes, K., Funk, M., Vala, A., Giese, N., Herberg, F.W., Dübel, S., Hoheisel, J.D. (2016).
    Utilisation of antibody microarrays for the selection of specific and informative antibodies from recombinant library binders of unknown quality.
    N Biotechnol 33, 574–581. https://doi.org/10.1016/j.nbt.2015.12.003
  • Betzen, C., Alhamdani, M.S.S., Lueong, S., Schröder, C., Stang, A., Hoheisel, J.D. (2015) 
    Clinical proteomics: Promises, challenges and limitations of affinity arrays.
    PROTEOMICS – Clinical Applications 9, 342–347. https://doi.org/10.1002/prca.201400156
  • Nijaguna, M.B., Schröder, C., Patil, V., Shwetha, S.D., Hegde, A.S., Chandramouli, B.A., Arivazhagan, A., Santosh, V., Hoheisel, J.D., Somasundaram, K. (2015) 
    Definition of a serum marker panel for glioblastoma discrimination and identification of Interleukin 1β in the microglial secretome as a novel mediator of endothelial cell survival induced by C-reactive protein.
    Journal of Proteomics 128, 251–261. https://doi.org/10.1016/j.jprot.2015.07.026
  • Srinivasan, H., Allory, Y., Sill, M., Vordos, D., Alhamdani, M.S.S., Radvanyi, F., Hoheisel, J.D., Schröder, C. (2014) 
    Prediction of recurrence of non muscle-invasive bladder cancer by means of a protein signature identified by antibody microarray analyses.
    PROTEOMICS 14, 1333–1342. https://doi.org/10.1002/pmic.201300320
  • Hoheisel, J.D., Alhamdani, M.S.S., Schröder, C. (2013) 
    Affinity-based microarrays for proteomic analysis of cancer tissues.
    PROTEOMICS – Clinical Applications 7, 8–15. https://doi.org/10.1002/prca.201200114
  • Schröder, C., Srinivasan, H., Sill, M., Linseisen, J., Fellenberg, K., Becker, N., Nieters, A., Hoheisel, J.D. (2013) 
    Plasma protein analysis of patients with different B-cell lymphomas using high-content antibody microarrays.
    PROTEOMICS – Clinical Applications 7, 802–812. https://doi.org/10.1002/prca.201300048
  • Alhamdani, M.S.S., Youns, M., Buchholz, M., Gress, T.M., Beckers, M.-C., Maréchal, D., Bauer, A., Schröder, C., Hoheisel, J.D. (2012) 
    Immunoassay-based proteome profiling of 24 pancreatic cancer cell lines.
    Journal of Proteomics, 3747–3759. https://doi.org/10.1016/j.jprot.2012.04.042
  • Alhamdani, M.S.S., Schröder, C., Hoheisel, J.D. (2010) 
    Analysis conditions for proteomic profiling of mammalian tissue and cell extracts with antibody microarrays.
    PROTEOMICS 10, 3203–3207. https://doi.org/10.1002/pmic.201000170
  • Alhamdani, M.S.S., Schröder, C., Werner, J., Giese, N., Bauer, A., Hoheisel, J.D. (2010).
    Single-Step Procedure for the Isolation of Proteins at Near-Native Conditions from Mammalian Tissue for Proteomic Analysis on Antibody Microarrays.
    J. Proteome Res. 9, 963–971. https://doi.org/10.1021/pr900844q
  • Schröder, C., Jacob, A., Tonack, S., Radon, T.P., Sill, M., Zucknick, M., Rüffer, S., Costello, E., Neoptolemos, J.P., Crnogorac-Jurcevic, T., Bauer, A., Fellenberg, K., Hoheisel, J.D. (2010).
    Dual-color Proteomic Profiling of Complex Samples with a Microarray of 810 Cancer-related Antibodies.
    Molecular & Cellular Proteomics 9, 1271–1280. https://doi.org/10.1074/mcp.M900419-MCP200
  • Sill, M., Schröder, C., Hoheisel, J.D., Benner, A., Zucknick, M. (2010).
    Assessment and optimisation of normalisation methods for dual-colour antibody microarrays.
    BMC Bioinformatics 11, 556. https://doi.org/10.1186/1471-2105-11-556
  • Kusnezow, W., Banzon, V., Schröder, C., Schaal, R., Hoheisel, J.D., Rüffer, S., Luft, P., Duschl, A., Syagailo, Y.V. (2007).
    Antibody microarray-based profiling of complex specimens: systematic evaluation of labeling strategies.
    PROTEOMICS 7, 1786–1799. https://doi.org/10.1002/pmic.200600762

 

Presentations at Scientific Conferences 

2023

Alenazi, F.Schmidt, R.Schroder, C. et al (2023)
14 Metformin does not reverse the effect of pharmacological inhibition of protein phosphatase 2A on VE-cadherin in human microvascular endothelial cells
Scottish Cardiovascular Forum – 26th annual meeting 
https://doi.org/10.1136/heartjnl-SCF-2023.14

Ceton, L., Koedoot, E., Sijsenaar, T., Montero Garcia, M., Grillet, F., van der Valk, J., Weber, K., Schoenauer, R., Hufnagel, K., Schmidt, R., Stroh, N., Boekhoff, H., de Kroon, C., van Altena, A., van der Meer, D., Vader, W., Ottevanger, N., Kroep, J. (2023)
Interpretation of patient-specific ex vivo immunotherapy response for ovarian cancer [abstract].
Proceedings of the AACR-NCI-EORTC Virtual International Conference on Molecular Targets and Cancer Therapeutics; 2023 Oct 11-15; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2023;22(12 Suppl):Abstract nr PR001. 
https://doi.org/10.1158/1535-7163.TARG-23-PR001

Kenzelmann, A., Boch, C., Schulz, M., Challagundla, M., Just, D.,Klein, M., Griesbeck, A., Schroeder, C. and Richter, M.(2023) Exploration of novel biomarkers for neurodegenerative diseases using ligand-binding assays. Alzheimer’sDement.2023;19(Suppl.14):e076362 , presented at the Alzheimer's Association International Conference (AAIC) 2023, July 16-20, Amsterdam, Netherlands; a collaboration of AbbVie and sciomics 
https://doi.org/10.1002/alz.076362

Kokol, M.Romano, A.Werner, E. et al (2023)
#383 BioEndoCar: identifying candidate biomarkers for diagnosis and prognosis of endometrial carcinoma using machine learning and artificial intelligence
ESGO 2023 Congress
https://doi.org/10.1136/ijgc-2023-ESGO.778

Swiatek-de Lange, M., Schroeder, C., Klein, M., Huang, J. and Strobl, M. (2023) 
Identification of biomarkers for prediction of dengue deterioration, presented at 6th Asia Dengue Summit (ADS 2023), 15-16 June 2023, Bangkok, Thailand; a collaboration of Roche Diagnostics and Sciomics

 

Schmidt, R., Schwamborn, J., Klein, M., Richter, M., Schulz, M. and Schroeder, C. (2022)
In-depth molecular profiling of Parkinson’s disease using advanced Minibrain models, presented at the International Conference on Alzheimer’s and Parkinson’s Diseases (AD/PD 2022), March 15-20, Barcelona, Spain, a collaboration of AbbVie, OrganoTherapeutics and Sciomics 

 

2021

Hafner, E., Smrkolj, Š., Romano, Werner, H. M. J., Semczuk, A., Kaminska, A., Adamiak-Godlewska, A., Fishman, D., Vilo, J., Lowy, C., Schröder, C., Janina Tokarz, J., Adamski, J., Weinberger, V., Bednaříková, M., Vinklerova, P., Ferrero, S., Barra, F., Takač, I., Knez, J., Lanišnik Rižner T. (2021)
BioEndoCar: in search of new Biomarkers for Diagnosis and Prognosis of Endometrial Carcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2021; 2021 Apr 10-15 and May 17-21. Philadelphia (PA): AACR; Cancer Res 2021;81(13_Suppl):Abstract nr 464. 
https://doi.org/10.1158/1538-7445.AM2021-464

Henriques, A., Rouvière, L., Griesbeck, A., Schmidt, R., Schroeder, C., Farrugia, C., Poindron, P., Callizot, N. (2021)
Neuroinflammation induced by amyloid beta 1-42 oligomers contributes to neuronal loss in an in vitro model of Alzheimer’s disease
Alzheimer’sDement.2021;17(Suppl.3):e054212. First published: 01 February 2022
https://doi.org/10.1002/alz.054212

Schroeder, C., Schmidt, R., Klein, M., Griesbeck, A., Richter, M., Schulz, M. (2021)
Identification of new biomarker signatures for neurodegenerative diseases, presented at the International Conference on Alzheimer’s and Parkinson’s Diseases (AD/PD 2021), a collaboration of AbbVie and Sciomics  

 

Selected Patents with Contribution of our Microarray Platform

  • WO2021175863A1: Method for diagnosis and/or prognosis of liver disease progression and risk of hepatocellular carcinoma and discovery of therapeutic compounds and targets to treat liver disease and cancer
  • WO2021162554A1: Means and methods for determining mesenchymal stromal cell properties.
  • US20210137912A1: s)-2-(1-(5-(cyclohexylcarbamoyl)-6-(propylthio)pyridin-2-yl)piperidin-3-yl)acetic acid for use in medicine
  • EP2536844B1US9551035B2: Means and methods for diagnosing pancreatic cancer
  • EP2718720B1US9678075B2: Prediction of recurrence for bladder cancer by a protein signature in tissue samples

Article | Biomarkers for canine mammary neoplasia

| Mai 2023 | New Article: Galadima et al. used the scioCD assay to analyse canine blood samples in the context of mammary neoplasia. The proteins CD20, CD45RA and CD99 were found at altered levels. The findings were validated by Western Blotting and are suggested as novel serum biomarkers.

Galadima et al. Canine Mammary Neoplasia Induces Variations in the Peripheral Blood Levels of CD20, CD45RA, and CD99 (2023) Int. J. Mol. Sci. 24(11)

Article | The Lifestyle Modifications Affect the Endometrial Proteome

| June 2022 | In a study by D. Abdulkhalikova et al. Endometrial Proteome changes werde identified impacted by Lifestyle modification in woman with Polycystic Ovarian Syndrome and Obesity.

Abdulkhalikova, DR. et al. The Lifestyle Modifications and Endometrial Proteome Changes of Women With Polycystic Ovary Syndrome and Obesity. Front. Endocrinol. 2022 in press.

Article | ETV6 levels predict outcome in DLBCL

| Jan 2022 | Erich Piovan and collegues at University of Padua collaborated with Sciomics to study specific biomarkers in FFPE tissue samples of DLBCL patients by custom antibody microarrays.

Marino, D. et al. High ETV6 Levels Support Aggressive B Lymphoma Cell Survival and Predict Poor Outcome in Diffuse Large B-Cell Lymphoma Patients. Cancers 14, (2022).

Article | Microbiota influences chemotherapy in pancreatic cancer

| February 2023 | New Article: In the study Tintelnot et al. identified a microbiota-derived metabolite that has clinical implications in the treatment of pancreatic cancer. Sciomics supported the authors by a protein profiling study of tumours derived from a mouse model upon treatment with 3-IAA and Firinox.

Tintelnot et al. Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer. Nature 615, 168-174 (2023)

Article | Prevention of Cyclosp.-A mediated anemia and peritubular loss

| June 2022 | In a study by Robert Labes et al. insights in prevention of cyclosporine mediated anemia and peritubular capillary loss were identified.

Labes, R. et al. Daprodust. prevents cyclosp.-A mediated anemia and peritubular capillary loss. Kidney International 2022 in press.

Article | Parkinson's Disease analysed via brain organoids

| Oct 2021 | In a study led by University of Luxembourg and OrganoTherapeutics SARL-S we used our scioPhospho assay to analyse the reaction of a brain organoid model for Parkinson's disease to certain treatments.

Jarazo, J. et al. (2021) ‘Parkinson's Disease Phenotypes in Patient Neuronal Cultures and Brain Organoids Improved by 2-Hydroxy...’, Movement Disorders, in press: doi: 10.1002/mds.28810 (Please get in touch for fulltext).

 

Article | HAPLN1 potentiates peritoneal metastasis in pancreatic cancer

| April 2023 | New Article: Wiedmann et al. identified HAPLN1 as a prognostic marker and as a and as a driver for peritoneal metastasis in pancreatic cancer. Sciomics contributed a plasma protein profiling of a mouse model to support this exciting study.

Wiedmann L et al. HAPLN1 potentiates peritoneal metastasis in pancreatic cancer. Nature Communications 14,2354 (2023)

Article | Cycle-dependent biomarkers in endometriosis

| May 2022 | In a study by Maja Pušić et al. Cycle-dependent plasma protein biomarkers for peritoneal endometriosis were identified by our scioDiscover platform.

Pušić, M. et al. Antibody Arrays Identified Cycle-Dependent Plasma Biomarker Candidates of Peritoneal Endometriosis. J. Pers. Med. 202212, 852.

Article | Biomarker identification and verification in endometriosis

| 22th Oct 2021 | Scientists at University Medical Centre Ljubljana used our scioDiscover platform for a biomarker identification in endometriosis:

"Discovery proteomics using antibody microarrays that covered 1360 proteins identified 16 proteins with different levels in cases versus the control patients. The validation using an ELISA approach confirmed significant differences in the levels of cartilage oligomeric matrix protein (COMP) and transforming growth factor-β-induced protein ig-h3 (TGFBI) and nonsignificant differences in angiotensinogen (AGT). "

 Janša, V. et al. (2021) ‘Proteomic analysis of peritoneal fluid identified COMP and TGFBI as new candidate biomarkers for endometriosis’, Scientific Reports, 11:20870. doi: 10.1038/s41598-021-00299-2. 

biomarkers in endometriosis

 

Article | Predicting a severe Covid-19 disease

| April 2023 | New Article: In a protein biomarker development project initiated by Sciomics, we have identified protein biomarker panels predicting development of a severe Covid.19  disease.

Hufnagel K., Fathi A. et al. Discovery and systematic assessment of early biomarkers that predict progression to severe COVID-19 disease. Communications Medicine 3,51 (2023)

Article | Co-Expression of microRNAs and Proteins in Alzheimer’s Disease

| Jan 2022 | In a study by Valentina di Pietro at Birmingham University our scioDoiscover platform was used to analyse the co-expression of proteins and microRNAs in the brains of Alzheimer's disease patients.

Watson, C. N. et al. Co-Expression Analysis of microRNAs and Proteins in Brain of Alzheimer’s Disease Patients. Cells 11, 163 (2022).

Article | Anti-cancer activity and mechanism of action of metformin in endometrial cancer cells

| March 2021 | Scientists at Heidelberg University Hospital characterized the protein profile response of an endometrial cell line to Metformin treatment and hyperinsulinemia  with our scioDiscover platform:

"The presented data helps identify potential targets affected by metformin treatment in EC and allows for a better understanding of the mechanism of action of the biguanide drug’s anti-cancer activity.

With the presented data, we contribute to a better understanding of the anti-cancer activity of metformin as well as its underlying mechanism of action in EC cells."

Lange, C. et al. (2021) ‘Changes in protein expression due to metformin treatment and hyperinsulinemia in a human endometrial cancer cell line’, PLoS ONE 16(3):e0248103. https://doi.org/10.1371/journal.pone.0248103