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Integrating single-cell analysis & proteomics for precision medicine 

 

Multi-Omics collaboration of Singleron and Sciomics

Powering breakthrough research using Multiomics

 

Singleron and Sciomics – Collaborating in the pursuit of Precision Medicine


Singleron Biotechnologies and Sciomics have a common goal: Precision Medicine. Their scientific approaches, however, seem to come from two sides of a coin. Consequently, their strategic alliance is expected to reach complementary and interlocking scientific findings in the quest of holistic disease research.


Cologne and Heidelberg, Germany, 30 May 2023

Singleron Biotechnologies, a front-runner in single cell multi-omics sequencing solutions and Sciomics, a first-class provider of explorative proteomic and post translational modification profiling platforms, announce their collaboration to advance Precision Medicine.

Singleron Biotechnologies is an innovative single cell sequencing solution provider with a focus on molecular diagnostics. They apply ground-breaking single cell analysis techniques for clinical diagnosis, drug development, and health management. Sciomics’ powerful proteomic and post-translational modification profiling platform provides in-depth insights on protein levels to clients from biotech and pharma industry and is internally used to develop innovative biomarker signatures.

“At Singleron we believe that single cell sequencing and analysis is vital to understand complex disease mechanisms to evolve increasingly individualized medicine” said Dr. Andreas Schmidt, Senior Vice President of Global Business Development at Singleron. “This new relationship between Singleron and Sciomics offers a synergistic approach to understand the multiple layers of cellular regulation”.

“Over the last decade we developed an efficient and robust platform for profiling protein levels and phosphorylation status.”, said Dr. Christoph Schröder, Chief Executive Officer at Sciomics. “By combining multiple omics technologies, we believe significant advances can be facilitated in the area of precision medicine.”

Together, their strategically combined expertise integrates single cell analyses with cutting-edge technology for biomarkers, profiling pathway activity and soluble markers and is expected to deliver innovative and novel insights accelerating advancements in personalized medicine promoting human health.


About Singleron

Founded in 2018, Singleron develops and commercializes single cell multi-omics products that can be used in both research and clinical settings. Its current product portfolio includes instruments, microfluidic devices, reagents, software analysis and database solutions that facilitate high-throughput single cell analysis. Singleron’s sample services offer expert execution and generation of high-quality results for academia, clinics, and biotech.

The company currently has offices, laboratories, and manufacturing facilities in Germany, Singapore, China, and the US. Its products are used in over 2,000 laboratories in hospitals, research institutes, and pharmaceutical companies.


About Sciomics

Sciomics has extensive expertise in the field of biomarker discovery, in vitro and in vivo. Their model system characterisation and disease mechanism profiling use high-content protein and post-translational modification profiling. Currently, this results in over 1,400 analysed proteins by using their proprietary fully immuno-based scioDiscover antibody array platform in a single assay with minimal sample requirements combined with Machine Learning assisted data analysis. The high-content and high-throughput platform guarantees robust and reproducible results which can be easily translated into validation and clinical assays. Sciomics serves customers world-wide, focussing on the European and North American market.

 

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News

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| October 2025 | In a porcine lung injury model, transpulmonary pressure–guided PEEP titration improved mechanics and reduced tidal stress. Sciomics supported the study by analysing cytokine, chemokine, and surface marker expression levels in plasma samples using the scioCD Precision Proteomics platform.

Mutschler et al., Optimizing Positive End-Expiratory Pressure in Asymmetric Acute Lung Injury in a Porcine Model: The Role of Transpulmonary Pressure. Int. J. Mol. Sci. 2025, 26, 9985  
Article | Long-Term Biobanked Dental Pulp Stem Cells Retain Angiogenic Potential

| September 2025 | Biobanked dental pulp stem cells preserved for years retained their angiogenic capacity and stem cell phenotype. Sciomics supported the study by analysing cell differentiation marker profiles from dental pulp stem cells using the scioCD Precision Proteomics platform.

Yamada et al., Long-Term Biobanked Dental Pulp Stem Cells Retain Angiogenic Potential for Vascularised Tissue Engineering—Laboratory Investigation. Int. Endod. J. (2025, online ahead of print)
Article | Fibroblast–monocyte signalling via TLR4 drives TNBC metastasis

| September 2025 | A TLR4-dependent axis between fibroblasts and monocytes in tumor-draining lymph nodes drives metastasis in triple-negative breast cancer. Sciomics provided protein profiling of lymph node and tumor samples to map surface- and immune-related protein changes using the scioCD protein profiling platform.

Mattavelli et al., A TLR4-dependent fibroblast-monocyte axis in tumor-draining lymph nodes contributes to metastasis in triple-negative breast cancer. Immunity. 2025 Sep 15 (online ahead of print)  
Article | Extracorporeal photopheresis alters cytokine profile in CTCL

| September 2025 | ECP rapidly modulates cytokine levels and immune cell composition in CTCL patients, revealing strong systemic immune effects. Sciomics‘ scioCD platform was used to profile plasma proteins and identify cytokine and surface marker changes in CTCL patients.

Melchers et al., Extracorporeal photopheresis therapy rapidly changes the cytokine profile and tumor microenvironment in cutaneous T cell lymphoma. Front Immunol. 2025;16:1669015  
Article | Lactate-driven immune hotspots resolved via SLC5A12 blockade

| August 2025 | Lactate signaling induces cytokine production and T/B cell clustering in Sjögren’s disease, and SLC5A12 blockade reverses these effects. Sciomics contributed to this study by comparing protein abundance and acetylation levels of murine cells using the scioDiscover protein profiling platform.

Certo, M, et al.. Lactate signalling leads to aggregation of immune-inflammatory hotspots and SLC5A12 blockade promotes their resolution. Nat Metab. 2025;7(8):1663-1680.  

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Testimonials

PD Dr. med. Mascha O. Fiedler-Kalenka and Dr. med. Benjamin Seybold

Heidelberg University Hospital, Department of Anesthesiology, Heidelberg, GermanyGerman Center for Lung Research (DZL), Translational Lung Research Center Heidelberg (TLRC), Heidelberg, Germany

"From the very beginning, working with the friendly and highly competent team at Sciomics was both professional and refreshingly straightforward. We particularly valued their openness to our specific research questions and the expert support they provided in planning and interpreting our exploratory cytokine analysis in a preclinical lung injury model. Communication was always on equal footing, enriched by Sciomics’ deep expertise, which also sparked new ideas for future projects."

Product: scioCD

Tara Sigdel, PhD

Associate Professor, Department of Surgery, University of California San Francisco

"We collaborated with Sciomics GmbH in Germany to analyze proteomics data from blood samples of kidney transplant recipients and liver perfusates during normothermic machine perfusion. Throughout the process, Sciomics provided exceptional support, ensuring timely data delivery and valuable assistance with data analysis. Their expertise and commitment have been instrumental in advancing our research, and we are currently using their data in multiple manuscript submissions. I highly recommend Sciomics for their reliable service and expertise in proteomics."

Product: scioDiscover

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