PEPperPRINT and Sciomics announce Partnership Agreement

 

Heidelberg, 18th November, 2014

 

Sciomics and PEPperPRINT agreed on a partnership for the co-distribution and co-marketing of their product and service portfolios with the aim to provide a comprehensive microarray toolbox for antibody characterization and biomarker discovery.

 

A joint two-step process for antibody characterization will enable the selection of the optimal antibody from a set of antibody candidates for therapeutic, diagnostic or research purposes. Sciomics will offer its custom antibody microarray platform as well as protein arrays for target binding validation and cross-reactivity analysis. Selected candidates will be further characterized by epitope mapping and epitope substitution scans provided by PEPperPRINT to identify conserved and variable amino acids as well as possible cross-reactions from a bioinformatics analysis of conserved core motifs.

 

The combination of peptide and antibody microarrays by PEPperPRINT and Sciomics further provides a powerful approach for discovery, in-depth characterization and validation of new serum biomarkers including antibodies and serum proteins. A combination of the core strengths of the respective platforms enables a robust and cost-efficient discovery of protein as well as autoantibody biomarker candidates in a highly multiplexed fashion. This increases the likelihood of identifying the optimal biomarker candidates and furthermore can increase the assay accuracy by combining information derived from both platforms.

 

The partnership agreement is based on a long lasting research relationship and highest appreciation of Sciomics scientific competences. A combination of the core technologies of both companies allows customers to benefit from our complementary and powerful microarray tool box” says Dr. Volker Stadler, CEO of PEPperPRINT. “The fact that both companies are located in Heidelberg certainly facilitates logistics and scientific collaboration and underlines the strength of the Heidelberg biotech cluster.”

 

"Sciomics is very glad to have entered into a partnership with PEPperPRINT. This complements our own expertise and portfolio in antibody characterization with the strong expertise of the PEPperPRINT team." says Dr. Christoph Schröder, CEO of Sciomics. "For biomarker research, combining the powerful microarray platforms of PEPperPRINT and Sciomics enables a most comprehensive coverage of all topics concerning discovery, verification as well as in-depth characterization of biomarker candidates. This partnership enables us to provide the maximum amount of value to our customer's projects."

 

Click here for Press Release as pdf-file.

 

 

 

 

PEPperPRINT
Dr. Lisa Steinbrück
Head of Business Development
Rischerstr. 12
D-69123 Heidelberg
Germany

Phone: +49 (0)6221 72644-89
Fax : +49 (0)6221 72644-75
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
Web: www.pepperprint.com

Sciomics GmbH
Dr. Ronny Schmidt
Business Development
Schneidmühlstr. 19
D-69115 Heidelberg
Germany

Phone:
+49 (0) 6221 3283140
Fax :
+49 (0) 6221 4294834
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
Web: https://www.sciomics.de

Our service portfolio

scioPhospho: protein profiling and phosphorylation status

scioPhospho: protein profiling and phosphorylation status

scioPhospho combines the advantages of a robust and cost-efficient protein expression profiling using scioDiscover with information on phosphorylation status. This combination provides a comprehensive overview on signalling events and pathway activity regulation. Features 1,300 highly relevant proteins are profiled in a single assay Phosphorylation status combined with protein expression levels…
Read more
scioDiscover - Protein Profiling on expression level

scioDiscover - Protein Profiling on expression level

Knowledge about protein expression levels is of utmost importance to predict toxic effects, estimate adverse effects of drug candidates and to identify new drug targets. Sciomics has a highly optimised…
scioCD - Cell surface marker and Cytokine profiling

scioCD - Cell surface marker and Cytokine profiling

  Characterise a certain cell type?   Cell composition in a certain tissue sample?   In-depth profiling of CD-marker expression?   Increase your throughput at high sensitivity levels? You aim…
scioUbi

scioUbi

Protein & ubiquitination profiling scioUbi is a high-content protein expression and ubiquitination level analysis. With scioUbi you can analyse up to 1,000 proteins in a single assay.   Features Screen…
scioCyto : Cytokine profiling

scioCyto : Cytokine profiling

scioCyto : Cytokine profiling scioCyto is a high-content analysis service for multiplex cytokine and chemokine profiling on protein level. A great variety of samples such as plasma, tissue, cells or…

COVID-19 related activities and services

covid 19 portfolio web

News

New article | Anti-cancer activity and mechanism of action of metformin in endometrial cancer cells

| March 2021 | Scientists at Heidelberg University Hospital characterized the protein profile response of an endometrial cell line to Metformin treatment and hyperinsulinemia  with our scioDiscover platform:

"The presented data helps identify potential targets affected by metformin treatment in EC and allows for a better understanding of the mechanism of action of the biguanide drug’s anti-cancer activity.

With the presented data, we contribute to a better understanding of the anti-cancer activity of metformin as well as its underlying mechanism of action in EC cells."

Lange, C. et al. (2021) ‘Changes in protein expression due to metformin treatment and hyperinsulinemia in a human endometrial cancer cell line’, PLoS ONE 16(3):e0248103. https://doi.org/10.1371/journal.pone.0248103 

New article | Selective elimination of immunosuppressive T cells in patients with multiple myeloma

| Feb 2021 | Scientists at Heidelberg University Hospital used our scioCD  platform to profile CD8+SLAMF7+ cell cultures:

"High throughput screening of 351 different cytokines and immune proteins in the supernatants of the T cells cultures revealed strong upregulation of IL-6, IL-8, both vital survival factors for myeloma cells, and CXCL5, a chemokine that could enhance the frequency of CD4 Treg, in the cultures containing CD8+SLAMF7+ cells. IL-2 and IL-5 were upregulated in the control cultures without CD8+SLAMF7+ T cells, highlighting a more activated state in the control group and suggestion IL-6 and IL-8 as potential effector cytokines for the suppressive CD8+SLAMF7+ T cells."

Awwad, M. H. S. et al. (2021) ‘Selective elimination of immunosuppressive T cells in patients with multiple myeloma’, Leukemia, pp. 1–14. doi: 10.1038/s41375-021-01172-x.

 

New article | Analysis of the Differential Gene and Protein Expression Profiles of Corneal Epithelial Cells Stimulated with Alternating Current Electric Fields

| Feb 2021 | Scientists at Rostock University Medical Center used our scioCD  platform to Corneal Epithelial Cells stimulated with Alternating Current Electric Fields:

"Analysis of the protein array data revealed that the treatment of cells with AC EFs altered the expression of various protein products ... revealed activation of various diverse cellular signaling pathways in which TNF, MAPK, IL17, and PI3K-Akt signaling pathways were significantly impacted ..."

B. S. Kowtharapu et. al., „Analysis of the Differential Gene and Protein Expression Profiles of Corneal Epithelial Cells Stimulated with Alternating Current Electric Fields“, Genes, Bd. 12, Nr. 2, Art. Nr. 2, Feb. 2021, doi: 10.3390/genes12020299.

 

New article | BET-Inhibitor I-BET762 and PARP-Inhibitor Talazoparib Synergy in Small Cell Lung Cancer Cells

| Dec 2020 | Scientists at University of Sassari used our scioPhospho  platform to to analyse the synergy of BET and PARP inhibition in Small Cell Lung Cancer Cells:

"Among the I-BET762-associated and combination-associated differentially expressed proteins, 150 were common to both treatment conditions. ... Ranking I-BET762-associated and combination-associated DEPs by their differential expression revealed CHEK2 and PTEN to be among the top-downregulated proteins, whose deficiencies have been associated with HR defects and increased PARPi sensitivity. "

Fiorentino, F. P. et al. (2020) ‘BET-Inhibitor I-BET762 and PARP-Inhibitor Talazoparib Synergy in Small Cell Lung Cancer Cells’, International Journal of Molecular Sciences, 21(24). doi: 10.3390/ijms21249595.

 

New article | Activated Eosinophils Exert Antitumorigenic Activities in Colorectal Cancer

| Jan 2019 | In the article, scientists at Tel Aviv University used our scioDiscover platform to analyse tumor-associated eosinophils in colorectal cancer. The full article is published in Cancer Immunology Research.

 

Testimonials

Dr. Joachim Lupberger 

Institute for Viral and Liver Disease, Inserm U1110, University of Strasbourg, LabEx HepSYS, Strasbourg, France

"Our lab is focusing on the identification of minimal-invasive biomarkers for liver disease progression. A challenge of our humanized animal models for liver disease is the low volume of blood samples available, which did not pose any problem for the analysis. I was pleased by the prompt, friendly, and uncomplicated contact and was impressed by the results and the thorough report we received. The overall quality was excellent, which made us to continue using the service of Sciomics for follow-up projects analyzing patient material."

Product: scioPhospho

 

 Prof. Dr. Andreas Weigert 

Goethe-University Frankfurt, Faculty of Medicine, Institute of Biochemistry I, Frankfurt, Germany

"We were under considerable time pressure to gain comprehensive information about cytokine/chemokine levels in a mouse model of self-resolving inflammation. To add to our misery, we had only a small number of biological replicates to run the analyses. Thankfully, the team at Sciomics were able to come to our rescue by providing a very prompt analysis, without neglecting to properly communicate the procedure, potential caveats and other details. The whole process was a very satisfying experience, rather like working with committed colleagues than with a company, and we got great data out of the project. I do happily recommend working with Sciomics for targeted proteomics analyses."

Product: scioCD

 

Tweets