scioDiscover - Protein Expression Analysis Platform

Our scioDiscover service enables high-content, immuno-based analysis of various biological samples leading to a comprehensive overview of proteomic changes. Key pathways in various diseases such as cancer, neurological disorders and organ failure are covered. The technology was successfully applied in a variety of biomedical studies and to discover new biomarker signatures. Within the analysis, 1030 proteins are analysed in parallel. The scioDiscover protein array based service enables fast and targeted research while still offering a broad overview of potential changes on the protein level in your samples. 

 

ApplicationSample types - Sample requirementAdvantagesService includes
    
Signalling Pathway Profilingplasma/serum - 10 ulhigh-contentsample preparation
Immunsystem activation marker profilingtissue - 50 mg1030 proteins analysedprotein extraction
Transcription factor analysis cells - 5 million protein concentration measurements
Cancer pathway screeningcerebrospinal fluid - 30 ulbroad coverage of: protein quality control
Cell surface marker Profilingcell culture supernatant - 10-20 ml- signalling pathway proteins 
Profiling of apoptotic processes/ apoptosis pathway analysis  - transcription factorssample labelling
 others on request- apoptosis markersample purification
Disease mechanism profiling - markers for oxidative stresssample incubation on arrays
Pathway activation in stem cells  - cell surface markers 
Analysis of organ damage/failure models  - cytokines/chemokinesraw data acquisition
Response of cells and tissue models to oxidative stress analysis  data normalisation
Profiling proteomic changes for various cell culture conditions minimal sample requirementsdata analysis
  native matrixes (non-fractionated/non-depleted)statistical analysis
Molecular initiate event analysis sensitivity as ELISA or bettercomprehensive study report
Compound mode-of-action analysis   
Prediction markers for toxicological effects  fully immuno-based assay 
    
Biomarker Discovery Reliable dual-colour study design 
Drug Target Discovery high reproducibility, CV < 10% 
    
CD cell surface molecule expression in immune cells     

 

Target coverage - GO annotations

Biological Process Cellular Component Protein Classes  
cellular process (GO:0009987)438cell part (GO:0044464)172signaling molecule (PC00207)122
metabolic process (GO:0008152)410organelle (GO:0043226)97receptor (PC00197)113
response to stimulus (GO:0050896)228extracellular region (GO:0005576)60nucleic acid binding (PC00171)109
biological regulation (GO:0065007)220membrane (GO:0016020)59hydrolase (PC00121)77
developmental process (GO:0032502)172macromolecular complex (GO:0032991)47transcription factor (PC00218)71
immune system process (GO:0002376)145extracellular matrix (GO:0031012)28enzyme modulator (PC00095)67
localization (GO:0051179)116cell junction (GO:0030054)3cell adhesion molecule (PC00069)62
multicellular organismal process (GO:0032501)72synapse (GO:0045202)2defense/immunity protein (PC00090)52
apoptotic process (GO:0006915)67  cytoskeletal protein (PC00085)40
cellular component organization or biogenesis (GO:0071840)65  oxidoreductase (PC00176)31
biological adhesion (GO:0022610)60  kinase (PC00137)31
reproduction (GO:0000003)26  transporter (PC00227)27
locomotion (GO:0040011)4  transfer/carrier protein (PC00219)25
    calcium-binding protein (PC00060)20
    phosphatase (PC00181)20
    structural protein (PC00211)18
    extracellular matrix protein (PC00102)17
    cell junction protein (PC00070)17
    membrane traffic protein (PC00150)14

PLEASE NOTE: GO annotation terms may overlap 

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Reference customers:

Prof. Dr. Faikah Güler, Medical School Hanover, Germany

Julian Kamhieh-Milz, Charite, Berlin, Germany

 

Case study - Bladder Cancer

Case study - Acute Kidney Injury

 

Our service portfolio

scioPhospho: protein profiling and phosphorylation status

scioPhospho: protein profiling and phosphorylation status

scioPhospho combines the advantages of a robust and cost-efficient protein expression profiling using scioDiscover with information on phosphorylation status. This combination provides a comprehensive overview on signalling events and pathway activity regulation. Features 1030 highly relevant proteins are profiled in a single assay Phosphorylation status combined with protein expression levels…
Read more
scioDiscover - Protein Profiling on expression level

scioDiscover - Protein Profiling on expression level

Knowledge about protein expression levels is of utmost importance to predict toxic effects, estimate adverse effects of drug candidates and to identify new drug targets. Sciomics has a highly optimised…
scioCD - Cell surface marker and Cytokine profiling

scioCD - Cell surface marker and Cytokine profiling

Characterise a certain cell type ? Cell composition in a certain tissue sample ? In-depth profiling of CD-marker expression ? Increase your throughput at high sensitivity levels ? You aim…
scioSpot - Microarray Production

scioSpot - Microarray Production

Microarrays - tailor-made for you. With more than 10 years of experience, Sciomics is the ideal partner for designing and printing your antibody-, protein-, peptide- or DNA/RNA chips. Benefit from…
scioCD - Cell surface marker and Cytokine profiling_v2

scioCD - Cell surface marker and Cytokine profiling_v2

Characterise a certain cell type ? Cell composition in a certain tissue sample ? In-depth profiling of CD-marker expression ? Increase your throughput at high sensitivity levels ? You aim…

News

Meeting | EACR25

| June 30 - July 3 2018 | Meet us at the 25th Biennial Congress of the European Association for Cancer Research in Amsterdam. Please visit our booth 22 or get in touch for a scheduled appointment to learn more about our protein profiling services.

New article | Role of Corneal Stromal Cells on Epithelial Cell Function during Wound Healing

| February 2018 | Researchers at Rostock University Medical Center published an article on the role of Corneal Stromal Cells on Epithelial Cell Function during Wound Healing in the International Journal of Molecular Sciences.

> Customer Testimonial Bhavani Kowtharapu:

"I am really happy with service of Sciomics. Very friendly team and really fast service and we have the results in our hand including bioinformatics analysis within 2 weeks. Thank you Sciomics team."

> More testimonials

Research | Participation in collaborative clinical studies for the treatment of MCDS

| January 2018 | The multinational consortium MCDS-therapy has been granted 5.7 Million Euro by the European Commission for the development of novel therapeutic approaches in rare skeletal disorders. Sciomics' expertise with the antibody microarray technology herein serves as a valuable tool for biomarker identification and personalized treatment monitoring. > Press release

New article | Modeling Congenital Adrenal Hyperplasia and Testing Interventions for Adrenal Insufficiency Using Donor-Specific Reprogrammed Cells

| January 2018 | A scioDiscover protein microarray study contributed to an article in Cell Reports. In this study Gerard Ruiz-Babot et al. analysed a donor specific reprogramming of cells.

Customer testimonial Leonardo Guasti, PhD (senior author):

This has undoubtedly opened new avenues in our research. We have found the Sciomics team to be extremely helpful and efficient during the whole process, from advising the best strategy to the final interpretation of results.

> More testimonials

A glas full of hope | Ein Glas Hoffnung

| January 2018 | Article on the StartUp Sciomics and our antibody microarray platform by our partner SCHOTT nexterion.

> English version "A glass full of hope"

> Deutsche Version "Ein Glas Hoffnung"

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