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Scientific articles & patents

Please find below selected patents and scientific articles on the antibody microarray platform or its application in biomedical studies for a protein profiling published in peer-reviewed journals. The articles were either published by our customers or by the founders and employees of Sciomics.

 

Selected scientific articles by our customers and partner

2022

  • Abdulkhalikova D, Sustarsic A, Vrtačnik Bokal E, Jancar N, Jensterle M and Burnik Papler T. 2022
    The Lifestyle Modifications and Endometrial Proteome Changes of Women With Polycystic Ovary Syndrome and Obesity.
    Front Endocrinol. 13:888460. doi:10.3389/fendo.2022.888460.
  • Franz S, Ertel A, Engel KM, Simon JC, Saalbach A. 2022
    Overexpression of S100A9 in obesity impairs macrophage differentiation via TLR4-NFkB-signaling worsening inflammation and wound healing.
    Theranostics. 12(4):1659-1682. doi:10.7150/thno.67174
  • Grötsch B., Schachtschabel E., Tripal P., Schmid B., Smith A., Schett G.A. and Bozec A. 2022
    Inflammatory activation of FcgR and IFNgR pathways co-influence the differentiation and activity of osteoclasts.
    Front. Immunol. 13:958974. doi:10.3389/fimmu.2022.958974
  • Labes R, Brinkmann L, Kulow VA, Roegner K, Mathia S, Balcerek B, Persson PB, Rosenberger C and Fähling M. 2022
    Daprodustat prevents cyclosporine-A mediated anemia and peritubular capillary loss.
    Kidney Int. S0085-2538(22)00375-1. doi:10.1016/j.kint.2022.04.025
  • Marino, D., Pizzi, M., Kotova, I., Schmidt, R., Schröder, C., Guzzardo, V., Talli, I., Peroni, E., Finotto, S., Scapinello, G., Dei Tos, A.P., Piazza, F., Trentin, L., Zagonel, V. and Piovan, E., 2022.
    High ETV6 Levels Support Aggressive B Lymphoma Cell Survival and Predict Poor Outcome in Diffuse Large B-Cell Lymphoma Patients.
    Cancers 14. https://doi.org/10.3390/cancers14020338
  • Pušić M, Klančič T, Knific T, Vogler A, Schmidt R, Schröder C and Lanišnik Rižner T. 2022.
    Antibody Arrays Identified Cycle-Dependent Plasma Biomarker Candidates of Peritoneal Endometriosis.
    J Pers Med. 12(6):852. doi: 10.3390/jpm12060852.
  • Watson, C.N., Begum, G., Ashman, E., Thorn, D., Yakoub, K.M., Hariri, M.A., Nehme, A., Mondello, S., Kobeissy, F., Belli, A. and Di Pietro, V., 2022.
    Co-Expression Analysis of microRNAs and Proteins in Brain of Alzheimer’s Disease Patients.
    Cells 11, 163. https://doi.org/10.3390/cells11010163

2021

  • Awwad, M.H.S., Mahmoud, A., Bruns, H., Echchannaoui, H., Kriegsmann, K., Lutz, R., Raab, M.S., Bertsch, U., Munder, M., Jauch, A., Weisel, K., Maier, B., Weinhold, N., Salwender, H.J., Eckstein, V., Hänel, M., Fenk, R., Dürig, J., Brors, B., Benner, A., Müller-Tidow, C., Goldschmidt, H., Hundemer, M., 2021.
    Selective elimination of immunosuppressive T cells in patients with multiple myeloma.
    Leukemia 35, 2602–2615. https://doi.org/10.1038/s41375-021-01172-x
  • Fomitcheva-Khartchenko, A., Rapsomaniki, M.A., Sobottka, B., Schraml, P., Kaigala, G.V., 2021
    Spatial protein heterogeneity analysis in frozen tissues to evaluate tumor heterogeneity.
    PLOS ONE 16, e0259332. https://doi.org/10.1371/journal.pone.0259332

  • Janša, V., Klančič, T., Pušić, M., Klein, M., Vrtačnik Bokal, E., Ban Frangež, H., Rižner, T.L., 2021.
    Proteomic analysis of peritoneal fluid identified COMP and TGFBI as new candidate biomarkers for endometriosis.
    Sci Rep 11, 20870. https://doi.org/10.1038/s41598-021-00299-2
  • Jarazo, J., Barmpa, K., Modamio, J., Saraiva, C., Sabaté‐Soler, S., Rosety, I., Griesbeck, A., Skwirblies, F., Zaffaroni, G., Smits, L.M., Su, J., Arias‐Fuenzalida, J., Walter, J., Gomez‐Giro, G., Monzel, A.S., Qing, X., Vitali, A., Cruciani, G., Boussaad, I., Brunelli, F., Jäger, C., Rakovic, A., Li, W., Yuan, L., Berger, E., Arena, G., Bolognin, S., Schmidt, R., Schröder, C., Antony, P.M.A., Klein, C., Krüger, R., Seibler, P., Schwamborn, J.C., 2021.
    Parkinson’s Disease Phenotypes in Patient Neuronal Cultures and Brain Organoids Improved by 2‐Hydroxypropyl‐β‐CyclodextrinTreatment.
    Mov Disord mds.28810. https://doi.org/10.1002/mds.28810
  • Kowtharapu, B.S., Damaraju, J., Singh, N.K., Ziebart, J., Bader, R., Koczan, D., Stachs, O., 2021.
    Analysis of the Differential Gene and Protein Expression Profiles of Corneal Epithelial Cells Stimulated with Alternating Current Electric Fields.
    Genes 12, 299. https://doi.org/10.3390/genes12020299
  • Lange, C., Weber, A.M., Schmidt, R., Schroeder, C., Strowitzki, T., Germeyer, A., 2021.
    Changes in protein expression due to metformin treatment and hyperinsulinemia in a human endometrial cancer cell line.
    PLOS ONE 16, e0248103. https://doi.org/10.1371/journal.pone.0248103

2020

  • Boberg, E., Kadri, N., Winterling, J., Davies, L.C., Björklund, A., Msghina, M., Iacobaeus, E., Le Blanc, K., 2020.
    Mental fatigue after allogeneic hematopoietic stem cell transplantation is associated with cognitive dysfunction, but not central nervous system inflammation.
    Haematologica 105, e310–e314. https://doi.org/10.3324/haematol.2019.225326
  • Fernando, R., Wardelmann, K., Deubel, S., Kehm, R., Jung, T., Mariotti, M., Vasilaki, A., Gladyshev, V.N., Kleinridders, A., Grune, T., Castro, J.P., 2020.
    Low steady-state oxidative stress inhibits adipogenesis by altering mitochondrial dynamics and decreasing cellular respiration.
    Redox Biology 32, 101507. https://doi.org/10.1016/j.redox.2020.101507
  • Fiorentino, F.P., Marchesi, I., Schröder, C., Schmidt, R., Yokota, J., Bagella, L., 2020.
    BET-Inhibitor I-BET762 and PARP-Inhibitor Talazoparib Synergy in Small Cell Lung Cancer Cells.
    Int J Mol Sci 21. https://doi.org/10.3390/ijms21249595
  • Yin, Y., Shelke, G.V., Lässer, C., Brismar, H., Lötvall, J., 2020.
    Extracellular vesicles from mast cells induce mesenchymal transition in airway epithelial cells.
    Respiratory Research 21, 101. https://doi.org/10.1186/s12931-020-01346-8

2019 and older

  • Fultang, L., Gamble, L.D., Gneo, L., Berry, A.M., Egan, S.A., De Bie, F., Yogev, O., Eden, G.L., Booth, S., Brownhill, S., Vardon, A., McConville, C.M., Cheng, P.N., Norris, M.D., Etchevers, H.C., Murray, J., Ziegler, D.S., Chesler, L., Schmidt, R., Burchill, S.A., Haber, M., De Santo, C., Mussai, F., 2019.
    Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma.
    Cancer Res 79, 611–624. https://doi.org/10.1158/0008-5472.CAN-18-2139
  • Reichman, H., Itan, M., Rozenberg, P., Yarmolovski, T., Brazowski, E., Varol, C., Gluck, N., Shapira, S., Arber, N., Qimron, U., Karo-Atar, D., Lee, J.J., Munitz, A., 2019.
    Activated Eosinophils Exert Antitumorigenic Activities in Colorectal Cancer.
    Cancer Immunol Res 7, 388–400. https://doi.org/10.1158/2326-6066.CIR-18-0494
  • Kowtharapu, B.S., Murín, R., Jünemann, A.G.M., Stachs, O., 2018.
    Role of Corneal Stromal Cells on Epithelial Cell Function during Wound Healing.
    International Journal of Molecular Sciences 19, 464. https://doi.org/10.3390/ijms19020464
  • Peiro, J.L., Oria, M., Aydin, E., Joshi, R., Cabanas, N., Schmidt, R., Schroeder, C., Marotta, M., Varisco, B.M., 2018.
    Proteomic profiling of tracheal fluid in an ovine model of congenital diaphragmatic hernia and fetal tracheal occlusion.
    Am J Physiol Lung Cell Mol Physiol 315, L1028–L1041. https://doi.org/10.1152/ajplung.00148.2018
  • Thorenz, A., Derlin, K., Schröder, C., Dressler, L., Vijayan, V., Pradhan, P., Immenschuh, S., Jörns, A., Echtermeyer, F., Herzog, C., Chen, R., Rong, S., Bräsen, J.H., Kooten, C. van, Kirsch, T., Klemann, C., Meier, M., Klos, A., Haller, H., Hensen, B., Gueler, F., 2018.
    Enhanced activation of interleukin-10, heme oxygenase-1, and AKT in C5aR2-deficient mice is associated with protection from ischemia reperfusion injury–induced inflammation and fibrosis.
    Kidney International 94, 741–755. https://doi.org/10.1016/j.kint.2018.04.005
  • Hamidi, Z., Tejero, E., Schmidt, R., Tucker, R., Pedro, A., 2017.
    Identification of potential blood-derived extracellular vesicles biomarkers to diagnose and predict distant metastases in ER+ breast cancer patients.
    bioRxiv 202291. https://doi.org/10.1101/202291
  • Sass, F.A., Schmidt‐Bleek, K., Ellinghaus, A., Filter, S., Rose, A., Preininger, B., Reinke, S., Geissler, S., Volk, H.-D., Duda, G.N., Dienelt, A., 2017.
    CD31+ Cells From Peripheral Blood Facilitate Bone Regeneration in Biologically Impaired Conditions Through Combined Effects on Immunomodulation and Angiogenesis.
    Journal of Bone and Mineral Research 32, 902–912. https://doi.org/10.1002/jbmr.3062
  • Bakdash, G., Buschow, S.I., Gorris, M.A.J., Halilovic, A., Hato, S.V., Sköld, A.E., Schreibelt, G., Sittig, S.P., Torensma, R., Duiveman-de Boer, T., Schröder, C., Smits, E.L., Figdor, C.G., de Vries, I.J.M., 2016.
    Expansion of a BDCA1+CD14+ Myeloid Cell Population in Melanoma Patients May Attenuate the Efficacy of Dendritic Cell Vaccines.
    Cancer Res 76, 4332–4346. https://doi.org/10.1158/0008-5472.CAN-15-1695

 

Selected scientific articles by our founders and employees

  • Marino, D., Pizzi, M., Kotova, I., Schmidt, R., Schröder, C., Guzzardo, V., Talli, I., Peroni, E., Finotto, S., Scapinello, G., Dei Tos, A.P., Piazza, F., Trentin, L., Zagonel, V., Piovan, E., 2022.
    High ETV6 Levels Support Aggressive B Lymphoma Cell Survival and Predict Poor Outcome in Diffuse Large B-Cell Lymphoma Patients.
    Cancers 14. https://doi.org/10.3390/cancers14020338
  • Jarazo, J., Barmpa, K., Modamio, J., Saraiva, C., Sabaté‐Soler, S., Rosety, I., Griesbeck, A., Skwirblies, F., Zaffaroni, G., Smits, L.M., Su, J., Arias‐Fuenzalida, J., Walter, J., Gomez‐Giro, G., Monzel, A.S., Qing, X., Vitali, A., Cruciani, G., Boussaad, I., Brunelli, F., Jäger, C., Rakovic, A., Li, W., Yuan, L., Berger, E., Arena, G., Bolognin, S., Schmidt, R., Schröder, C., Antony, P.M.A., Klein, C., Krüger, R., Seibler, P., Schwamborn, J.C., 2022.
    Parkinson’s Disease Phenotypes in Patient Neuronal Cultures and Brain Organoids Improved by 2‐Hydroxypropyl‐β‐CyclodextrinTreatment.
    Mov Disord mds.28810. https://doi.org/10.1002/mds.28810
  • Pušić M, Klančič T, Knific T, Vogler A, Schmidt R, Schröder C, Lanišnik Rižner T. 2022.
    Antibody Arrays Identified Cycle-Dependent Plasma Biomarker Candidates of Peritoneal Endometriosis.
    J Pers Med. 12(6):852. doi: 10.3390/jpm12060852.
  • Janša, V., Klančič, T., Pušić, M., Klein, M., Vrtačnik Bokal, E., Ban Frangež, H., Rižner, T.L., 2021.
    Proteomic analysis of peritoneal fluid identified COMP and TGFBI as new candidate biomarkers for endometriosis.
    Sci Rep 11, 20870. https://doi.org/10.1038/s41598-021-00299-2
  • Lange, C., Weber, A.M., Schmidt, R., Schroeder, C., Strowitzki, T., Germeyer, A., 2021.
    Changes in protein expression due to metformin treatment and hyperinsulinemia in a human endometrial cancer cell line.
    PLOS ONE 16, e0248103. https://doi.org/10.1371/journal.pone.0248103
  • Fiorentino, F.P., Marchesi, I., Schröder, C., Schmidt, R., Yokota, J., Bagella, L., 2020.
    BET-Inhibitor I-BET762 and PARP-Inhibitor Talazoparib Synergy in Small Cell Lung Cancer Cells.
    International Journal of Molecular Sciences 21, 9595. https://doi.org/10.3390/ijms21249595
  • Fultang, L., Gamble, L.D., Gneo, L., Berry, A.M., Egan, S.A., Bie, F.D., Yogev, O., Eden, G.L., Booth, S., Brownhill, S., Vardon, A., McConville, C.M., Cheng, P.N., Norris, M.D., Etchevers, H.C., Murray, J., Ziegler, D.S., Chesler, L., Schmidt, R., Burchill, S.A., Haber, M., Santo, C.D., Mussai, F., 2019.
    Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma.
    Cancer Res 79, 611–624. https://doi.org/10.1158/0008-5472.CAN-18-2139
  • Thorenz, A., Derlin, K., Schröder, C., Dressler, L., Vijayan, V., Pradhan, P., Immenschuh, S., Jörns, A., Echtermeyer, F., Herzog, C., Chen, R., Rong, S., Bräsen, J.H., Kooten, C. van, Kirsch, T., Klemann, C., Meier, M., Klos, A., Haller, H., Hensen, B., Gueler, F., 2018.
    Enhanced activation of interleukin-10, heme oxygenase-1, and AKT in C5aR2-deficient mice is associated with protection from ischemia reperfusion injury–induced inflammation and fibrosis.
    Kidney International 94, 741–755. https://doi.org/10.1016/j.kint.2018.04.005
  • Peiro, J.L., Oria, M., Aydin, E., Joshi, R., Cabanas, N., Schmidt, R., Schroeder, C., Marotta, M., Varisco, B.M., 2018.
    Proteomic profiling of tracheal fluid in an ovine model of congenital diaphragmatic hernia and fetal tracheal occlusion.
    American Journal of Physiology-Lung Cellular and Molecular Physiology 315, L1028–L1041. https://doi.org/10.1152/ajplung.00148.2018
  • Bakdash, G., Buschow, S.I., Gorris, M.A.J., Halilovic, A., Hato, S.V., Sköld, A.E., Schreibelt, G., Sittig, S.P., Torensma, R., Boer, T.D., Schröder, C., Smits, E.L., Figdor, C.G., Vries, I.J.M. de, 2016.
    Expansion of a BDCA1+CD14+ Myeloid Cell Population in Melanoma Patients May Attenuate the Efficacy of Dendritic Cell Vaccines.
    Cancer Res 76, 4332–4346. https://doi.org/10.1158/0008-5472.CAN-15-1695
  • Kibat, J., Schirrmann, T., Knape, M.J., Helmsing, S., Meier, D., Hust, M., Schröder, C., Bertinetti, D., Winter, G., Pardes, K., Funk, M., Vala, A., Giese, N., Herberg, F.W., Dübel, S., Hoheisel, J.D., 2016.
    Utilisation of antibody microarrays for the selection of specific and informative antibodies from recombinant library binders of unknown quality.
    N Biotechnol 33, 574–581. https://doi.org/10.1016/j.nbt.2015.12.003
  • Betzen, C., Alhamdani, M.S.S., Lueong, S., Schröder, C., Stang, A., Hoheisel, J.D., 2015.
    Clinical proteomics: Promises, challenges and limitations of affinity arrays.
    PROTEOMICS – Clinical Applications 9, 342–347. https://doi.org/10.1002/prca.201400156
  • Nijaguna, M.B., Schröder, C., Patil, V., Shwetha, S.D., Hegde, A.S., Chandramouli, B.A., Arivazhagan, A., Santosh, V., Hoheisel, J.D., Somasundaram, K., 2015.
    Definition of a serum marker panel for glioblastoma discrimination and identification of Interleukin 1β in the microglial secretome as a novel mediator of endothelial cell survival induced by C-reactive protein.
    Journal of Proteomics 128, 251–261. https://doi.org/10.1016/j.jprot.2015.07.026
  • Srinivasan, H., Allory, Y., Sill, M., Vordos, D., Alhamdani, M.S.S., Radvanyi, F., Hoheisel, J.D., Schröder, C., 2014.
    Prediction of recurrence of non muscle-invasive bladder cancer by means of a protein signature identified by antibody microarray analyses.
    PROTEOMICS 14, 1333–1342. https://doi.org/10.1002/pmic.201300320
  • Hoheisel, J.D., Alhamdani, M.S.S., Schröder, C., 2013.
    Affinity-based microarrays for proteomic analysis of cancer tissues.
    PROTEOMICS – Clinical Applications 7, 8–15. https://doi.org/10.1002/prca.201200114
  • Schröder, C., Srinivasan, H., Sill, M., Linseisen, J., Fellenberg, K., Becker, N., Nieters, A., Hoheisel, J.D., 2013.
    Plasma protein analysis of patients with different B-cell lymphomas using high-content antibody microarrays.
    PROTEOMICS – Clinical Applications 7, 802–812. https://doi.org/10.1002/prca.201300048
  • Alhamdani, M.S.S., Youns, M., Buchholz, M., Gress, T.M., Beckers, M.-C., Maréchal, D., Bauer, A., Schröder, C., Hoheisel, J.D., 2012.
    Immunoassay-based proteome profiling of 24 pancreatic cancer cell lines.
    Journal of Proteomics, 3747–3759. https://doi.org/10.1016/j.jprot.2012.04.042
  • Alhamdani, M.S.S., Schröder, C., Hoheisel, J.D., 2010.
    Analysis conditions for proteomic profiling of mammalian tissue and cell extracts with antibody microarrays.
    PROTEOMICS 10, 3203–3207. https://doi.org/10.1002/pmic.201000170
  • Alhamdani, M.S.S., Schröder, C., Werner, J., Giese, N., Bauer, A., Hoheisel, J.D., 2010.
    Single-Step Procedure for the Isolation of Proteins at Near-Native Conditions from Mammalian Tissue for Proteomic Analysis on Antibody Microarrays.
    J. Proteome Res. 9, 963–971. https://doi.org/10.1021/pr900844q
  • Schröder, C., Jacob, A., Tonack, S., Radon, T.P., Sill, M., Zucknick, M., Rüffer, S., Costello, E., Neoptolemos, J.P., Crnogorac-Jurcevic, T., Bauer, A., Fellenberg, K., Hoheisel, J.D., 2010.
    Dual-color Proteomic Profiling of Complex Samples with a Microarray of 810 Cancer-related Antibodies.
    Molecular & Cellular Proteomics 9, 1271–1280. https://doi.org/10.1074/mcp.M900419-MCP200
  • Sill, M., Schröder, C., Hoheisel, J.D., Benner, A., Zucknick, M., 2010.
    Assessment and optimisation of normalisation methods for dual-colour antibody microarrays.
    BMC Bioinformatics 11, 556. https://doi.org/10.1186/1471-2105-11-556
  • Kusnezow, W., Banzon, V., Schröder, C., Schaal, R., Hoheisel, J.D., Rüffer, S., Luft, P., Duschl, A., Syagailo, Y.V., 2007.
    Antibody microarray-based profiling of complex specimens: systematic evaluation of labeling strategies.
    PROTEOMICS 7, 1786–1799. https://doi.org/10.1002/pmic.200600762

 

Selected patents with contribution of our platform

  • WO2021175863A1: Method for diagnosis and/or prognosis of liver disease progression and risk of hepatocellular carcinoma and discovery of therapeutic compounds and targets to treat liver disease and cancer
  • WO2021162554A1: Means and methods for determining mesenchymal stromal cell properties.
  • US20210137912A1: s)-2-(1-(5-(cyclohexylcarbamoyl)-6-(propylthio)pyridin-2-yl)piperidin-3-yl)acetic acid for use in medicine
  • EP2536844B1US9551035B2: Means and methods for diagnosing pancreatic cancer
  • EP2718720B1US9678075B2: Prediction of recurrence for bladder cancer by a protein signature in tissue samples

Our service portfolio

scioPhospho: protein profiling and phosphorylation status

scioPhospho: protein profiling and phosphorylation status

scioPhospho combines the advantages of a robust and cost-efficient protein expression profiling using scioDiscover with information on phosphorylation status. This combination provides a comprehensive overview on signalling events and pathway activity regulation. Features 1,300 highly relevant proteins are profiled in a single assay Phosphorylation status combined with protein expression levels…
Read more
scioDiscover - Protein Profiling on expression level

scioDiscover - Protein Profiling on expression level

Knowledge about protein expression levels is of utmost importance to predict toxic effects, estimate adverse effects of drug candidates and to identify new drug targets. Sciomics has a highly optimised…
scioCD - Cell surface marker and Cytokine profiling

scioCD - Cell surface marker and Cytokine profiling

  Characterise a certain cell type?   Cell composition in a certain tissue sample?   In-depth profiling of CD-marker expression?   Increase your throughput at high sensitivity levels? You aim…
scioUbi

scioUbi

Protein & ubiquitination profiling scioUbi is a high-content protein expression and ubiquitination level analysis. With scioUbi you can analyse up to 1,000 proteins in a single assay.   Features Screen…
scioCyto : Cytokine profiling

scioCyto : Cytokine profiling

scioCyto : Cytokine profiling scioCyto is a high-content analysis service for multiplex cytokine and chemokine profiling on protein level. A great variety of samples such as plasma, tissue, cells or…

COVID-19 related activities and services

covid 19 portfolio web

News

New article | Prevention of Cyclosp.-A mediated anemia and peritubular loss

| June 2022 | In a study by Robert Labes et al. insights in prevention of cyclosporine mediated anemia and peritubular capillary loss were identified.

Labes, R. et al. Daprodust. prevents cyclosp.-A mediated anemia and peritubular capillary loss. Kidney International 2022 in press.
New article | The Lifestyle Modifications Affect the Endometrial Proteome

| June 2022 | In a study by D. Abdulkhalikova et al. Endometrial Proteome changes werde identified impacted by Lifestyle modification in woman with Polycystic Ovarian Syndrome and Obesity.

Abdulkhalikova, DR. et al. The Lifestyle Modifications and Endometrial Proteome Changes of Women With Polycystic Ovary Syndrome and Obesity. Front. Endocrinol. 2022 in press.
New article | Cycle-dependent biomarkers in endometriosis

| May 2022 | In a study by Maja Pušić et al. Cycle-dependent plasma protein biomarkers for peritoneal endometriosis were identified by our scioDiscover platform.

Pušić, M. et al. Antibody Arrays Identified Cycle-Dependent Plasma Biomarker Candidates of Peritoneal Endometriosis. J. Pers. Med. 202212, 852.
New article | Co-Expression of microRNAs and Proteins in Alzheimer’s Disease

| Jan 2022 | In a study by Valentina di Pietro at Birmingham University our scioDoiscover platform was used to analyse the co-expression of proteins and microRNAs in the brains of Alzheimer's disease patients.

Watson, C. N. et al. Co-Expression Analysis of microRNAs and Proteins in Brain of Alzheimer’s Disease Patients. Cells 11, 163 (2022).
New article | ETV6 levels predict outcome in DLBCL

| Jan 2022 | Erich Piovan and collegues at University of Padua collaborated with Sciomics to study specific biomarkers in FFPE tissue samples of DLBCL patients by custom antibody microarrays.

Marino, D. et al. High ETV6 Levels Support Aggressive B Lymphoma Cell Survival and Predict Poor Outcome in Diffuse Large B-Cell Lymphoma Patients. Cancers 14, (2022).

Testimonials

Dr. Bettina Grötsch

Department of Medicine 3 - Rheumatology and Immunology, University Clinics Erlangen, Erlangen, Germany

"Our lab is working with human osteoclast that were isolated and differentiated from human peripheral blood. Therefore, we were quite limited in cell numbers and protein content for our planned Phosphoprotein analyses. Nonetheless, Sciomics and especially Camille Lowy helped us a lot to test and improve our protein isolation techniques to achieve some interesting phosphoproteome data in human osteoclasts. We were really impressed by the detailed data report and their willingness to discuss and reanalyze the data repeatedly until we got the best results out of our measurements. Even several month after their first report, we could ask for help and suggestions with an immediate reply.  The phosphoproteome analyses completed our preliminary project data and are now published in Frontiers Immunology.  Altogether, we were very happy with the service of Sciomics and special thanks to Camille Lowy and Christoph Schröder who guided us through the whole process."

Product: scioPhospho
Publication: Grötsch B. et al. 2022 Front. Immunol. 13:958974 

Alenka Djarmila Behsen, PhD candidate

Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway

"The process of working with Ronny and his colleagues at Sciomics has been very easy and efficient. Response time is very quick and they are always available for meetings when you have more questions. Would definitely recommend working with Sciomics."

Product: scioCD

 

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