scioSpot - Custom Protein Arrays

Protein Microarrays - manufactured exactly to your requirements. With more than 10 years of experience, Sciomics is the ideal partner for designing and printing your Protein Arrays for various applications. Benefit from excellent quality manufacturing and a wide choice of microarray support surfaces and coupling-chemistry optimised for your application.

 

Possible applications:

  • Multiplexed autoimmune biomarker detection 
  • Patient stratification according to autoimmune biomarker profiles for Precision Medicine applications
  • Diagnostic tests for point-of-care IVD
  • Autoantibody Biomarker development
  • Autoimmune fingerprint profiling
  • Protein-Protein Interaction studies
  • Enzyme substrate discovery and investigation
  • Protein-DNA Interaction studies

 

Key advantages:

  • Highly-parallel analysis from the same sample in one experiment
  • Dual-colour experimental design improves robustness  
  • High sensitivity
  • High reproducibility (CV <10%)
  • Low sample consumption
  • Batch sizes from 1 up to 2.000 arrays, low batch-to-batch variation
  • Production is scalable as and when required 
  • Stringent microarray quality control

 

This email address is being protected from spambots. You need JavaScript enabled to view it. for further details and to discuss your custom protein array production.

scioSpot - Custom Peptide Microarrays

Peptide Microarrays - manufactured exactly to your requirements. Using innovative laser-based technology for designing and printing custom Peptide Arrays we provide you with exactly the peptide composition you need. Fast turn-around times and cost-efficient manufacturing enables various study sizes from one microarray to hundreds.  

 

Possible applications:

  • Multiplexed autoimmune biomarker detection 
  • Autoantibody Biomarker development
  • Epitope Mapping
  • Detection of anti-pathogen antibodies
  • Detection of disease specific antibodies for e.g. HIV, Tuberculosis, CMV and Hepatitis
  • Autoimmune fingerprint profiling
  • Protein-Peptide Interaction studies

 

 Key advantages:

  • Highly-parallel analysis from the same sample in one experiment
  • Very cost-efficient even for low sample numbers
  • Production of a single slides possible  
  • Low sample consumption
  • Production is scalable as and when required 
  • Stringent microarray quality control

 

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scioSpot - Custom DNA Arrays

DNA Microarrays - tailor-made for you. With more than 10 years of experience, Sciomics is the ideal partner for designing and printing your DNA arrays as well as RNA arrays. Benefit from excellent quality manufacturing and a wide choice of microarray support surfaces and coupling-chemistry optimised for your application.

 

Possible applications:

  • Diagnostic tests such as point-of-care SNP detection
  • Multiplexed pathogen detection for infectious diseases or food safety applications
  • Patient stratification according to SNP for Precision Medicine applications
  • DNA and RNA Biomarker development
  • In-depth gene expression profiling
  • Comparitive genomic studies
  • Detection of alternative splicing e.g. for oncological indications
  • Obtain and correlate genomic or transcriptomic data with protein expression data

 Key advantages:

  • Highly-parallel DNA/RNA analysis from the same sample in one experiment
  • Dual-colour experimental design improves robustness  
  • High sensitivity
  • High reproducibility (CV <13%)
  • Low sample consumption
  • Batch sizes from 1 up to 2.000 arrays, low batch-to-batch variation
  • Production is scalable as and when required 
  • Stringent microarray quality control

 

Reference customers:

Hutman Diagnostics, Switzerland

Dr. Stéphanie Renaud, University of Lausanne, Switzerland

 

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scioDiscover - Protein Expression Analysis Platform

Our scioDiscover service enables high-content, immuno-based analysis of various biological samples leading to a comprehensive overview of proteomic changes. Key pathways in various diseases such as cancer, neurological disorders and organ failure are covered. The technology was successfully applied in a variety of biomedical studies and to discover new biomarker signatures. Within the analysis, 1030 proteins are analysed in parallel. The scioDiscover protein array based service enables fast and targeted research while still offering a broad overview of potential changes on the protein level in your samples. 

 

ApplicationSample types - Sample requirementAdvantagesService includes
    
Signalling Pathway Profilingplasma/serum - 10 ulhigh-contentsample preparation
Immunsystem activation marker profilingtissue - 50 mg1030 proteins analysedprotein extraction
Transcription factor analysis cells - 5 million protein concentration measurements
Cancer pathway screeningcerebrospinal fluid - 30 ulbroad coverage of: protein quality control
Cell surface marker Profilingcell culture supernatant - 10-20 ml- signalling pathway proteins 
Profiling of apoptotic processes/ apoptosis pathway analysis  - transcription factorssample labelling
 others on request- apoptosis markersample purification
Disease mechanism profiling - markers for oxidative stresssample incubation on arrays
Pathway activation in stem cells  - cell surface markers 
Analysis of organ damage/failure models  - cytokines/chemokinesraw data acquisition
Response of cells and tissue models to oxidative stress analysis  data normalisation
Profiling proteomic changes for various cell culture conditions minimal sample requirementsdata analysis
  native matrixes (non-fractionated/non-depleted)statistical analysis
Molecular initiate event analysis sensitivity as ELISA or bettercomprehensive study report
Compound mode-of-action analysis   
Prediction markers for toxicological effects  fully immuno-based assay 
    
Biomarker Discovery Reliable dual-colour study design 
Drug Target Discovery high reproducibility, CV < 10% 
    
CD cell surface molecule expression in immune cells     

 

Target coverage - GO annotations

Biological Process Cellular Component Protein Classes  
cellular process (GO:0009987)438cell part (GO:0044464)172signaling molecule (PC00207)122
metabolic process (GO:0008152)410organelle (GO:0043226)97receptor (PC00197)113
response to stimulus (GO:0050896)228extracellular region (GO:0005576)60nucleic acid binding (PC00171)109
biological regulation (GO:0065007)220membrane (GO:0016020)59hydrolase (PC00121)77
developmental process (GO:0032502)172macromolecular complex (GO:0032991)47transcription factor (PC00218)71
immune system process (GO:0002376)145extracellular matrix (GO:0031012)28enzyme modulator (PC00095)67
localization (GO:0051179)116cell junction (GO:0030054)3cell adhesion molecule (PC00069)62
multicellular organismal process (GO:0032501)72synapse (GO:0045202)2defense/immunity protein (PC00090)52
apoptotic process (GO:0006915)67  cytoskeletal protein (PC00085)40
cellular component organization or biogenesis (GO:0071840)65  oxidoreductase (PC00176)31
biological adhesion (GO:0022610)60  kinase (PC00137)31
reproduction (GO:0000003)26  transporter (PC00227)27
locomotion (GO:0040011)4  transfer/carrier protein (PC00219)25
    calcium-binding protein (PC00060)20
    phosphatase (PC00181)20
    structural protein (PC00211)18
    extracellular matrix protein (PC00102)17
    cell junction protein (PC00070)17
    membrane traffic protein (PC00150)14

PLEASE NOTE: GO annotation terms may overlap 

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Reference customers:

Prof. Dr. Faikah Güler, Medical School Hanover, Germany

Julian Kamhieh-Milz, Charite, Berlin, Germany

 

Case study - Bladder Cancer

Case study - Acute Kidney Injury

 

scioSpec - Antibody Specificity Assessment

Be sure that your antibody is fit for your application. Profile your therapeutic or diagnostic antibody against more than 9000 human proteins. Have a comprehensive cross-reactivity and off-target reactivity profile at hand. Our comprehensive antibody specificity screening service offers you a tailored study design, experimental conditions according to your requirements as well as comprehensive data and statistical analysis. Benefit from our long-standing experience in the microarray field and robust, fully-automated experimental workflows. 

    

Features

  • Comprehensive sample-to-result analysis service including data analysis
  • Comprehensive data analysis and report formats available
  • Customer specific Study Design Service available 
  • Fully automated experimental procedures
  • Highly parallel screening against more than 9.000 human proteins
  • Proteins carry eukaryotic post translational modifications (PTM)
  • All protein classes covered within the analysis

 

Applications

  • Comprehensive therapeutic and diagnostic antibody specificity/reactivity profiling
  • Profile off-target interactions and cross reactions of your antibody
  • Profile interactions with related proteins (e.g. kinases, cell surface proteins, CD marker)
  • Determine therapeutically relevant interactions

 

 

Overview of protein classes covered within the analysis service:

Download complete protein content list here

Protein Class

No. on array

Protein kinases (unique)

268

Protein kinases (including domains, splice variants and mutants)

776

Transcription factors

328

Membrane protins

2,635

Nuclear proteins

2,252

Signal transduction

1,526

Secreted proteins

192

Cell communication

1,687

Metabolism

3,862

Cell death

505

Protease/peptidase activity

219

Please note: Protein classes may overlap.

 

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Subcategories