scioSpec - Antibody Specificity Assessment

Be sure that your antibody is fit for your application. Profile your therapeutic or diagnostic antibody against more than 9000 human proteins. Have a comprehensive cross-reactivity and off-target reactivity profile at hand. Our comprehensive antibody specificity screening service offers you a tailored study design, experimental conditions according to your requirements as well as comprehensive data and statistical analysis. Benefit from our long-standing experience in the microarray field and robust, fully-automated experimental workflows. 

    

Features

  • Comprehensive sample-to-result analysis service including data analysis
  • Comprehensive data analysis and report formats available
  • Customer specific Study Design Service available 
  • Fully automated experimental procedures
  • Highly parallel screening against more than 9.000 human proteins
  • Proteins carry eukaryotic post translational modifications (PTM)
  • All protein classes covered within the analysis

 

Applications

  • Comprehensive therapeutic and diagnostic antibody specificity/reactivity profiling
  • Profile off-target interactions and cross reactions of your antibody
  • Profile interactions with related proteins (e.g. kinases, cell surface proteins, CD marker)
  • Determine therapeutically relevant interactions

 

 

Overview of protein classes covered within the analysis service:

Download complete protein content list here

Protein Class

No. on array

Protein kinases (unique)

268

Protein kinases (including domains, splice variants and mutants)

776

Transcription factors

328

Membrane protins

2,635

Nuclear proteins

2,252

Signal transduction

1,526

Secreted proteins

192

Cell communication

1,687

Metabolism

3,862

Cell death

505

Protease/peptidase activity

219

Please note: Protein classes may overlap.

 

For further and more detailed information This email address is being protected from spambots. You need JavaScript enabled to view it..

 

 

 

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Products & Services

scioDiscover - Protein Expression Analysis

scioDiscover - Protein Expression Analysis

Our scioDiscover service enables high-content, immuno-based analysis of various biological samples leading to a comprehensive overview of proteomic changes. Key pathways in various diseases such as cancer, neurological disorders and organ failure are covered. The technology was successfully applied in a variety of biomedical studies and to discover new biomarker…
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scioDiscover - Protein Expression Level Profiling

scioDiscover - Protein Expression Level Profiling

Knowledge about protein expression levels is of utmost importance to predict toxic effects, estimate adverse effects of drug candidates and to identify new drug targets. Sciomics has a highly optimised range of protein profiling services available. These help you to speed up your research and generate important data at lower…
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scioPhospho: protein + phosphorylation profiling

scioPhospho: protein + phosphorylation profiling

scioPhospho combines the advantages of a robust and cost-efficient protein expression profiling using scioDiscover with information on phosphorylation status. This combination provides a comprehensive overview on signalling events and pathway…
scioCD - Cell surface marker and Cytokine profiling

scioCD - Cell surface marker and Cytokine profiling

Characterise a certain cell type ? Cell composition in a certain tissue sample ? In-depth profiling of CD-marker expression ? Increase your throughput at high sensitivity levels ? You aim…
scioDiscover - Protein Biomarker Discovery

scioDiscover - Protein Biomarker Discovery

Personalised Medicine and Diagnostic Research require techniques to discover and verify novel and more accurate Biomarkers. We offer a comprehensive immuno-based Protein Biomarker Discovery Service using complex Antibody Microarrays. This…
scioSpec - Antibody Specificity Assessment

scioSpec - Antibody Specificity Assessment

Be sure that your antibody is fit for your application. Profile your therapeutic or diagnostic antibody against more than 9000 human proteins. Have a comprehensive cross-reactivity and off-target reactivity profile…
scioExtract - Protein Extraction Buffers

scioExtract - Protein Extraction Buffers

The Scio-Extract Protein Extraction Buffers are optimised for superior protein isolation performance from all cell compartments and of membrane proteins. Their non-denaturing properties enable the extraction of active proteins under…
scioSpot - Custom Antibody Microarrays

scioSpot - Custom Antibody Microarrays

Antibody Microarrays - tailor-made for you. With more than 10 years of experience, Sciomics is the ideal partner for designing and printing your antibody chips as well as arrays of…
scioSpot - Microarray Production

scioSpot - Microarray Production

Microarrays - tailor-made for you. With more than 10 years of experience, Sciomics is the ideal partner for designing and printing your antibody-, protein-, peptide- or DNA/RNA chips. Benefit from…

News

New article | Expansion of a BDCA1+CD14+ Myeloid Cell Population in Melanoma Patients May Attenuate the Efficacy of Dendritic Cell Vaccines.

| July 2016 | One of our customer projects was published in Cancer Research. In this study Bakdash et al. analysed the expansion of a BDCA1+CD14+ myeloid cell population in the context of immune therapy of melanoma. Within this study a protein profiling of cellular patient samples was performed with scioCD antibody arrays.

Interview | Advanced Biomarkers for Precision Medicine

New article | Analysis of the blood protein profile in B-cell lymphoma patients

| 12.12.2013 | There is a new article in the current issue of Proteomics Clinical Applications on an analysis of the blood protein profile of different B-cell lymphoma using complex antibody microarrays. 200 blood samples from patients with Diffuse Large B-cell Lymphoma (DLBCL), Follicular Lymphoma (FL), Chronic Lymphocytic Leukemia (CLL) as well as healthy controls were analysed and compared with each other. The study identified proteins with discriminating power among the different lymphoma types, as well as subgroups within each lymphoma entity.

New article | Prediction of recurrence in bladder cancer

| 08.05.2014 | In a study published in Proteomics we identified proteins with differential abundance in bladder tumours with and without a local recurrence using antibody array technology. Next to interesting differences of the two tumour subtypes from a scientific point of view, we found a protein biomarker signature with high potential for a prognosis. This could enabling urologists in future to adjust the therapy and surveillance scheme accordingly. Further validation studies are ongoing. →Case study report

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