scioCD - Cell surface marker and Cytokine profiling_v2

 

Characterise a certain cell type ?

 

Cell composition in a certain tissue sample ?

 

In-depth profiling of CD-marker expression ?

 

Increase your throughput at high sensitivity levels ?

You aim at high reproducibility ?

 

 

Our scioCD profiling service covers 206 different proteins by monoclonal antibodies:

All these proteins can be analysed in parallel within a single experiment from minute sample amounts. Thereby, scioCD antibody array analysis service is ideally suited to investigate cell composition of tissues or the differentiation status of cultured cells in a highly parallel, fast and robust fashion. In addition, protein distribution in blood samples (plasma / serum) can be analysed efficiently, providing insights in the blood cell composition.

Combining analysis of signalling and cellular receptor proteins provides in-depth insights into signal transduction processes
Proteins profiled in parallel by scioCD antibody microarray and their interactions

scioCD is a complete sample-to-result service for a variety of different sample types. The respective protocols were developed over a period of 15 years and are optimised towards highest possible sensitivity combined with high reproducibility (coefficients of variation below 10%).

 

 

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Applications

  • profiling of cell differentiation status
  • stem cell differentiation 
  • investigate soluble CD-molecules for e.g. allograft rejection
  • inflammatory response profiling
  • immuno-oncology profiling of check-point inhibitor targets
  • characterisation of tissue-isolated primary cells
  • immune-cell surface marker profiling on
    • various B-cells 
    • stimulated T-cells
    • patient derived T-cells
    • patient derived dendritic cells
  • oncology profiling for new biomarkers e.g. Leukemia
  • tumor micro-environment profiling
  • profile response to stimuli of cell lines
  • evaluate protein expression changes in silencing/overexpression  experiments
 

Advantages

  • high content - 206 proteins are analysed with monoclonal antibodies
  • broad coverage and parallel analysis of
    • 129 CD molecules 
    • 54 cytokines and chemokines
    • 23 other relevant molecules (HLAs, p53)
  • minimal sample requirements
  • native matrixes ( non-fractionated / non-depleted )
  • sensitivity as ELISA or better
  • fully immuno-based assay
  • reliable dual-colour study design
  • high reproducibility, CV < 10%
  • most proteins are covered redundantly by two or more antibodies
  • each antibody is presented in four replicates
  • antibodies are available for follow-up studies


 

Which sample types can be analysed ?

Within our scioCD analysis service the following samples can be analysed:

  • plasma / serum
  • fresh frozen tissue samples
  • cellular content
  • cell culture supernatant
  • cerebrospinal fluid
  • additional sample types on request

  

Sample-to-result service

Within the analysis service, we will not only carry out the microarray experiments but also support you with a suggestion for an appropriate microarray study design as well as with the sample selection process in order to address your scientific question in the optimal way. Within 3-4 weeks after receipt of your samples you will receive a customised study report including a statistical analysis.

Our analysis service includes:

  • definition of an appropriate study design
  • sample preparation
  • protein extraction
  • protein concentration measurements
  • protein quality control
  • sample labelling
  • sample purification
  • incubation of the samples on antibody microarrays
  • microarray scanning
  • raw data acquisition
  • data normalisation
  • data analysis including cluster analysis
  • statistical testing for differentially abundant proteins
  • comprehensive study report

 

Target list for the scioCD protein profiling service:

 

CD Marker

 #

CD#

Uniprot_Entry

Gene

Gene names  (synonym )

Uniprot_ID

Protein name

1

CD1a

CD1A_HUMAN

CD1A

 

P06126

T-cell surface glycoprotein CD1a (T-cell surface antigen T6/Leu-6) (hTa1 thymocyte antigen) (CD antigen CD1a)

2

CD2

CD2_HUMAN

CD2

SRBC

P06729

T-cell surface antigen CD2 (Erythrocyte receptor) (LFA-2) (LFA-3 receptor) (Rosette receptor) (T-cell surface antigen T11/Leu-5) (CD antigen CD2)

3

CD3E

CD3E_HUMAN

CD3E

T3E

P07766

T-cell surface glycoprotein CD3 epsilon chain (T-cell surface antigen T3/Leu-4 epsilon chain) (CD antigen CD3e)

4

CD3G

CD3G_HUMAN

CD3G

T3G

P09693

T-cell surface glycoprotein CD3 gamma chain (T-cell receptor T3 gamma chain) (CD antigen CD3g)

5

CD4

CD4_HUMAN

CD4

 

P01730

T-cell surface glycoprotein CD4 (T-cell surface antigen T4/Leu-3) (CD antigen CD4)

6

CD5

CD5_HUMAN

CD5

LEU1

P06127

T-cell surface glycoprotein CD5 (Lymphocyte antigen T1/Leu-1) (CD antigen CD5)

7

CD6

CD6_HUMAN

CD6

 

P30203

T-cell differentiation antigen CD6 (T12) (TP120) (CD antigen CD6) [Cleaved into: Soluble CD6]

8

CD7

CD7_HUMAN

CD7

 

P09564

T-cell antigen CD7 (GP40) (T-cell leukemia antigen) (T-cell surface antigen Leu-9) (TP41) (CD antigen CD7)

9

CD8

CD8A_HUMAN

CD8A

MAL

P01732

T-cell surface glycoprotein CD8 alpha chain (T-lymphocyte differentiation antigen T8/Leu-2) (CD antigen CD8a)

10

CD9

CD9_HUMAN

CD9

MIC3 TSPAN29

P21926

CD9 antigen (5H9 antigen) (Cell growth-inhibiting gene 2 protein) (Leukocyte antigen MIC3) (Motility-related protein) (MRP-1) (Tetraspanin-29) (Tspan-29) (p24) (CD antigen CD9)

11

CD10

NEP_HUMAN

MME

EPN

P08473

Neprilysin (EC 3.4.24.11) (Atriopeptidase) (Common acute lymphocytic leukemia antigen) (CALLA) (Enkephalinase) (Neutral endopeptidase 24.11) (NEP) (Neutral endopeptidase) (Skin fibroblast elastase) (SFE) (CD antigen CD10)

12

CD11a

CD11A_HUMAN

CDK11A

CDC2L2 CDC2L3 PITSLREB

Q9UQ88

Cyclin-dependent kinase 11A (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 2) (Cell division protein kinase 11A) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L2)

13

CD11b

CD11B_HUMAN

CDK11B

CDC2L1 CDK11 PITSLREA PK58

P21127

Cyclin-dependent kinase 11B (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 1) (CLK-1) (Cell division protein kinase 11B) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L1) (p58 CLK-1)

14

CD11c

ITAX_HUMAN

ITGAX

CD11C

P20702

Integrin alpha-X (CD11 antigen-like family member C) (Leu M5) (Leukocyte adhesion glycoprotein p150,95 alpha chain) (Leukocyte adhesion receptor p150,95) (CD antigen CD11c)

15

CD13

AMPN_HUMAN

ANPEP

APN CD13 PEPN

P15144

Aminopeptidase N (AP-N) (hAPN) (EC 3.4.11.2) (Alanyl aminopeptidase) (Aminopeptidase M) (AP-M) (Microsomal aminopeptidase) (Myeloid plasma membrane glycoprotein CD13) (gp150) (CD antigen CD13)

16

CD14

CD14_HUMAN

CD14

 

P08571

Monocyte differentiation antigen CD14 (Myeloid cell-specific leucine-rich glycoprotein) (CD antigen CD14) [Cleaved into: Monocyte differentiation antigen CD14, urinary form; Monocyte differentiation antigen CD14, membrane-bound form]

17

CD15

     

18

CD16

FCG3A_HUMAN

FCGR3A

CD16A FCG3 FCGR3 IGFR3

P08637

Low affinity immunoglobulin gamma Fc region receptor III-A (CD16a antigen) (Fc-gamma RIII-alpha) (Fc-gamma RIII) (Fc-gamma RIIIa) (FcRIII) (FcRIIIa) (FcR-10) (IgG Fc receptor III-2) (CD antigen CD16a)

19

CD17

     

20

CD18

ITB2_HUMAN

ITGB2

CD18 MFI7

P05107

Integrin beta-2 (Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta) (Complement receptor C3 subunit beta) (CD antigen CD18)

21

CD19

CD19_HUMAN

CD19

 

P15391

B-lymphocyte antigen CD19 (B-lymphocyte surface antigen B4) (Differentiation antigen CD19) (T-cell surface antigen Leu-12) (CD antigen CD19)

22

CD20

CD20_HUMAN

MS4A1

CD20

P11836

B-lymphocyte antigen CD20 (B-lymphocyte surface antigen B1) (Bp35) (Leukocyte surface antigen Leu-16) (Membrane-spanning 4-domains subfamily A member 1) (CD antigen CD20)

23

CD21

CR2_HUMAN

CR2

C3DR

P20023

Complement receptor type 2 (Cr2) (Complement C3d receptor) (Epstein-Barr virus receptor) (EBV receptor) (CD antigen CD21)

24

CD22

CD22_HUMAN

CD22

SIGLEC2

P20273

B-cell receptor CD22 (B-lymphocyte cell adhesion molecule) (BL-CAM) (Sialic acid-binding Ig-like lectin 2) (Siglec-2) (T-cell surface antigen Leu-14) (CD antigen CD22)

25

CD23

FCER2_HUMAN

FCER2

CD23A CLEC4J FCE2 IGEBF

P06734

Low affinity immunoglobulin epsilon Fc receptor (BLAST-2) (C-type lectin domain family 4 member J) (Fc-epsilon-RII) (Immunoglobulin E-binding factor) (Lymphocyte IgE receptor) (CD antigen CD23) [Cleaved into: Low affinity immunoglobulin epsilon Fc receptor membrane-bound form; Low affinity immunoglobulin epsilon Fc receptor soluble form]

26

CD24

CD24_HUMAN

CD24

CD24A

P25063

Signal transducer CD24 (Small cell lung carcinoma cluster 4 antigen) (CD antigen CD24)

27

CD25

IL2RA_HUMAN

IL2RA

 

P01589

Interleukin-2 receptor subunit alpha (IL-2 receptor subunit alpha) (IL-2-RA) (IL-2R subunit alpha) (IL2-RA) (TAC antigen) (p55) (CD antigen CD25)

28

CD26

DPP4_HUMAN

DPP4

ADCP2 CD26

P27487

Dipeptidyl peptidase 4 (EC 3.4.14.5) (ADABP) (Adenosine deaminase complexing protein 2) (ADCP-2) (Dipeptidyl peptidase IV) (DPP IV) (T-cell activation antigen CD26) (TP103) (CD antigen CD26) [Cleaved into: Dipeptidyl peptidase 4 membrane form (Dipeptidyl peptidase IV membrane form); Dipeptidyl peptidase 4 soluble form (Dipeptidyl peptidase IV soluble form)]

29

CD27

CD27_HUMAN

CD27

TNFRSF7

P26842

CD27 antigen (CD27L receptor) (T-cell activation antigen CD27) (T14) (Tumor necrosis factor receptor superfamily member 7) (CD antigen CD27)

30

CD28

CD28_HUMAN

CD28

 

P10747

T-cell-specific surface glycoprotein CD28 (TP44) (CD antigen CD28)

31

CD29

ITB1_HUMAN

ITGB1

FNRB MDF2 MSK12

P05556

Integrin beta-1 (Fibronectin receptor subunit beta) (Glycoprotein IIa) (GPIIA) (VLA-4 subunit beta) (CD antigen CD29)

32

CD30

TNR8_HUMAN

TNFRSF8

CD30 D1S166E

P28908

Tumor necrosis factor receptor superfamily member 8 (CD30L receptor) (Ki-1 antigen) (Lymphocyte activation antigen CD30) (CD antigen CD30)

33

CD31

PECA1_HUMAN

PECAM1

 

P16284

Platelet endothelial cell adhesion molecule (PECAM-1) (EndoCAM) (GPIIA') (PECA1) (CD antigen CD31)

34

CD32

FCG2A_HUMAN

FCGR2A

CD32 FCG2 FCGR2A1 IGFR2

P12318

Low affinity immunoglobulin gamma Fc region receptor II-a (IgG Fc receptor II-a) (CDw32) (Fc-gamma RII-a) (Fc-gamma-RIIa) (FcRII-a) (CD antigen CD32)

35

CD33

CD33_HUMAN

CD33

SIGLEC3

P20138

Myeloid cell surface antigen CD33 (Sialic acid-binding Ig-like lectin 3) (Siglec-3) (gp67) (CD antigen CD33)

36

CD34

CD34_HUMAN

CD34

 

P28906

Hematopoietic progenitor cell antigen CD34 (CD antigen CD34)

37

CD35

CR1_HUMAN

CR1

C3BR

P17927

Complement receptor type 1 (C3b/C4b receptor) (CD antigen CD35)

38

CD36

CD36_HUMAN

CD36

GP3B GP4

P16671

Platelet glycoprotein 4 (Fatty acid translocase) (FAT) (Glycoprotein IIIb) (GPIIIB) (Leukocyte differentiation antigen CD36) (PAS IV) (PAS-4) (Platelet collagen receptor) (Platelet glycoprotein IV) (GPIV) (Thrombospondin receptor) (CD antigen CD36)

39

CD37

CD37_HUMAN

CD37

TSPAN26

P11049

Leukocyte antigen CD37 (Tetraspanin-26) (Tspan-26) (CD antigen CD37)

40

CD38

CD38_HUMAN

CD38

 

P28907

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (EC 3.2.2.6) (2'-phospho-ADP-ribosyl cyclase) (2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase) (EC 2.4.99.20) (2'-phospho-cyclic-ADP-ribose transferase) (ADP-ribosyl cyclase 1) (ADPRC 1) (Cyclic ADP-ribose hydrolase 1) (cADPr hydrolase 1) (T10) (CD antigen CD38)

41

CD39

ENTP1_HUMAN

ENTPD1

CD39

P49961

Ectonucleoside triphosphate diphosphohydrolase 1 (NTPDase 1) (EC 3.6.1.5) (Ecto-ATP diphosphohydrolase 1) (Ecto-ATPDase 1) (Ecto-ATPase 1) (Ecto-apyrase) (Lymphoid cell activation antigen) (CD antigen CD39)

42

CD40

TNR5_HUMAN

CD40

TNFRSF5

P25942

Tumor necrosis factor receptor superfamily member 5 (B-cell surface antigen CD40) (Bp50) (CD40L receptor) (CDw40) (CD antigen CD40)

43

CD41

ITA2B_HUMAN

ITGA2B

GP2B ITGAB

P08514

Integrin alpha-IIb (GPalpha IIb) (GPIIb) (Platelet membrane glycoprotein IIb) (CD antigen CD41) [Cleaved into: Integrin alpha-IIb heavy chain; Integrin alpha-IIb light chain, form 1; Integrin alpha-IIb light chain, form 2]

44

CD41a

 

ITGA2B

   

45

CD42b

GP1BA_HUMAN

GP1BA

 

P07359

Platelet glycoprotein Ib alpha chain (GP-Ib alpha) (GPIb-alpha) (GPIbA) (Glycoprotein Ibalpha) (Antigen CD42b-alpha) (CD antigen CD42b) [Cleaved into: Glycocalicin]

46

CD43

LEUK_HUMAN

SPN

CD43

P16150

Leukosialin (Galactoglycoprotein) (GALGP) (Leukocyte sialoglycoprotein) (Sialophorin) (CD antigen CD43)

47

CD44

CD44_HUMAN

CD44

LHR MDU2 MDU3 MIC4

P16070

CD44 antigen (CDw44) (Epican) (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Heparan sulfate proteoglycan) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44)

48

CD44s

     

49

CD45

PTPRC_HUMAN

PTPRC

CD45

P08575

Receptor-type tyrosine-protein phosphatase C (EC 3.1.3.48) (Leukocyte common antigen) (L-CA) (T200) (CD antigen CD45)

50

CD45RA

 

PTPRC

   

51

CD45RO

 

PTPRC

   

52

CD46

MCP_HUMAN

CD46

MCP MIC10

P15529

Membrane cofactor protein (TLX) (Trophoblast leukocyte common antigen) (CD antigen CD46)

53

CD47

CD47_HUMAN

CD47

MER6

Q08722

Leukocyte surface antigen CD47 (Antigenic surface determinant protein OA3) (Integrin-associated protein) (IAP) (Protein MER6) (CD antigen CD47)

54

CD47R

 

CD47

   

55

CD48

CD48_HUMAN

CD48

BCM1 BLAST1

P09326

CD48 antigen (B-lymphocyte activation marker BLAST-1) (BCM1 surface antigen) (Leukocyte antigen MEM-102) (SLAM family member 2) (SLAMF2) (Signaling lymphocytic activation molecule 2) (TCT.1) (CD antigen CD48)

56

CD49d

ITA4_HUMAN

ITGA4

CD49D

P13612

Integrin alpha-4 (CD49 antigen-like family member D) (Integrin alpha-IV) (VLA-4 subunit alpha) (CD antigen CD49d)

57

CD49e

ITA5_HUMAN

ITGA5

FNRA

P08648

Integrin alpha-5 (CD49 antigen-like family member E) (Fibronectin receptor subunit alpha) (Integrin alpha-F) (VLA-5) (CD antigen CD49e) [Cleaved into: Integrin alpha-5 heavy chain; Integrin alpha-5 light chain]

58

CD49f

ITA6_HUMAN

ITGA6

 

P23229

Integrin alpha-6 (CD49 antigen-like family member F) (VLA-6) (CD antigen CD49f) [Cleaved into: Integrin alpha-6 heavy chain; Integrin alpha-6 light chain; Processed integrin alpha-6 (Alpha6p)]

59

CD50

ICAM3_HUMAN

ICAM3

 

P32942

Intercellular adhesion molecule 3 (ICAM-3) (CDw50) (ICAM-R) (CD antigen CD50)

60

CD51

ITAV_HUMAN

ITGAV

MSK8 VNRA VTNR

P06756

Integrin alpha-V (Vitronectin receptor) (Vitronectin receptor subunit alpha) (CD antigen CD51) [Cleaved into: Integrin alpha-V heavy chain; Integrin alpha-V light chain]

61

CD52

CD52_HUMAN

CD52

CDW52 HE5

P31358

CAMPATH-1 antigen (CDw52) (Cambridge pathology 1 antigen) (Epididymal secretory protein E5) (Human epididymis-specific protein 5) (He5) (CD antigen CD52)

62

CD53

CD53_HUMAN

CD53

MOX44 TSPAN25

P19397

Leukocyte surface antigen CD53 (Cell surface glycoprotein CD53) (Tetraspanin-25) (Tspan-25) (CD antigen CD53)

63

CD54

ICAM1_HUMAN

ICAM1

 

P05362

Intercellular adhesion molecule 1 (ICAM-1) (Major group rhinovirus receptor) (CD antigen CD54)

64

CD55

DAF_HUMAN

CD55

CR DAF

P08174

Complement decay-accelerating factor (CD antigen CD55)

65

CD56

NCAM1_HUMAN

NCAM1

NCAM

P13591

Neural cell adhesion molecule 1 (N-CAM-1) (NCAM-1) (CD antigen CD56)

66

CD57

B3GA1_HUMAN

B3GAT1

GLCATP

Q9P2W7

Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 (EC 2.4.1.135) (Beta-1,3-glucuronyltransferase 1) (Glucuronosyltransferase P) (GlcAT-P) (UDP-GlcUA:glycoprotein beta-1,3-glucuronyltransferase) (GlcUAT-P)

67

CD58

LFA3_HUMAN

CD58

LFA3

P19256

Lymphocyte function-associated antigen 3 (Ag3) (Surface glycoprotein LFA-3) (CD antigen CD58)

68

CD59

CD59_HUMAN

CD59

MIC11 MIN1 MIN2 MIN3 MSK21

P13987

CD59 glycoprotein (1F5 antigen) (20 kDa homologous restriction factor) (HRF-20) (HRF20) (MAC-inhibitory protein) (MAC-IP) (MEM43 antigen) (Membrane attack complex inhibition factor) (MACIF) (Membrane inhibitor of reactive lysis) (MIRL) (Protectin) (CD antigen CD59)

69

CD61

ITB3_HUMAN

ITGB3

GP3A

P05106

Integrin beta-3 (Platelet membrane glycoprotein IIIa) (GPIIIa) (CD antigen CD61)

70

CD62E

LYAM2_HUMAN

SELE

ELAM1

P16581

E-selectin (CD62 antigen-like family member E) (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD antigen CD62E)

71

CD62L

LYAM1_HUMAN

SELL

LNHR LYAM1

P14151

L-selectin (CD62 antigen-like family member L) (Leukocyte adhesion molecule 1) (LAM-1) (Leukocyte surface antigen Leu-8) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (Lymph node homing receptor) (TQ1) (gp90-MEL) (CD antigen CD62L)

72

CD62p

LYAM3_HUMAN

SELP

GMRP GRMP

P16109

P-selectin (CD62 antigen-like family member P) (Granule membrane protein 140) (GMP-140) (Leukocyte-endothelial cell adhesion molecule 3) (LECAM3) (Platelet activation dependent granule-external membrane protein) (PADGEM) (CD antigen CD62P)

73

CD63

CD63_HUMAN

CD63

MLA1 TSPAN30

P08962

CD63 antigen (Granulophysin) (Lysosomal-associated membrane protein 3) (LAMP-3) (Melanoma-associated antigen ME491) (OMA81H) (Ocular melanoma-associated antigen) (Tetraspanin-30) (Tspan-30) (CD antigen CD63)

74

CD66acde

 

CEACAMs

   

75

CD66b

CEAM8_HUMAN

CEACAM8

CGM6

P31997

Carcinoembryonic antigen-related cell adhesion molecule 8 (CD67 antigen) (Carcinoembryonic antigen CGM6) (Non-specific cross-reacting antigen NCA-95) (CD antigen CD66b)

76

CD66e

CEAM5_HUMAN

CEACAM5

CEA

P06731

Carcinoembryonic antigen-related cell adhesion molecule 5 (Carcinoembryonic antigen) (CEA) (Meconium antigen 100) (CD antigen CD66e)

77

CD69

CD69_HUMAN

CD69

CLEC2C

Q07108

Early activation antigen CD69 (Activation inducer molecule) (AIM) (BL-AC/P26) (C-type lectin domain family 2 member C) (EA1) (Early T-cell activation antigen p60) (GP32/28) (Leukocyte surface antigen Leu-23) (MLR-3) (CD antigen CD69)

78

CD70

CD70_HUMAN

CD70

CD27L CD27LG TNFSF7

P32970

CD70 antigen (CD27 ligand) (CD27-L) (Tumor necrosis factor ligand superfamily member 7) (CD antigen CD70)

79

CD71

TFR1_HUMAN

TFRC

 

P02786

Transferrin receptor protein 1 (TR) (TfR) (TfR1) (Trfr) (T9) (p90) (CD antigen CD71) [Cleaved into: Transferrin receptor protein 1, serum form (sTfR)]

80

CD72

CD72_HUMAN

CD72

 

P21854

B-cell differentiation antigen CD72 (Lyb-2) (CD antigen CD72)

81

CD73

5NTD_HUMAN

NT5E

NT5 NTE

P21589

5'-nucleotidase (5'-NT) (EC 3.1.3.5) (Ecto-5'-nucleotidase) (CD antigen CD73)

82

CD79a

CD79A_HUMAN

CD79A

IGA MB1

P11912

B-cell antigen receptor complex-associated protein alpha chain (Ig-alpha) (MB-1 membrane glycoprotein) (Membrane-bound immunoglobulin-associated protein) (Surface IgM-associated protein) (CD antigen CD79a)

83

CD80

CD80_HUMAN

CD80

CD28LG CD28LG1 LAB7

P33681

T-lymphocyte activation antigen CD80 (Activation B7-1 antigen) (BB1) (CTLA-4 counter-receptor B7.1) (B7) (CD antigen CD80)

84

CD81

CD81_HUMAN

CD81

TAPA1 TSPAN28

P60033

CD81 antigen (26 kDa cell surface protein TAPA-1) (Target of the antiproliferative antibody 1) (Tetraspanin-28) (Tspan-28) (CD antigen CD81)

85

CD86

CD86_HUMAN

CD86

CD28LG2

P42081

T-lymphocyte activation antigen CD86 (Activation B7-2 antigen) (B70) (BU63) (CTLA-4 counter-receptor B7.2) (FUN-1) (CD antigen CD86)

86

CD95

TNR6_HUMAN

FAS

APT1 FAS1 TNFRSF6

P25445

Tumor necrosis factor receptor superfamily member 6 (Apo-1 antigen) (Apoptosis-mediating surface antigen FAS) (FASLG receptor) (CD antigen CD95)

87

CD97

CD97_HUMAN

CD97

 

P48960

CD97 antigen (Leukocyte antigen CD97) (CD antigen CD97) [Cleaved into: CD97 antigen subunit alpha; CD97 antigen subunit beta]

88

CD98

4F2_HUMAN

SLC3A2

MDU1

P08195

4F2 cell-surface antigen heavy chain (4F2hc) (4F2 heavy chain antigen) (Lymphocyte activation antigen 4F2 large subunit) (Solute carrier family 3 member 2) (CD antigen CD98)

89

CD99

CD99_HUMAN

CD99

MIC2 MIC2X MIC2Y

P14209

CD99 antigen (12E7) (E2 antigen) (Protein MIC2) (T-cell surface glycoprotein E2) (CD antigen CD99)

90

CD99R

 

CD99

   

91

CD103

ITAE_HUMAN

ITGAE

 

P38570

Integrin alpha-E (HML-1 antigen) (Integrin alpha-IEL) (Mucosal lymphocyte 1 antigen) (CD antigen CD103) [Cleaved into: Integrin alpha-E light chain; Integrin alpha-E heavy chain]

92

CD105

EGLN_HUMAN

ENG

END

P17813

Endoglin (CD antigen CD105)

93

CD106

VCAM1_HUMAN

VCAM1

 

P19320

Vascular cell adhesion protein 1 (V-CAM 1) (VCAM-1) (INCAM-100) (CD antigen CD106)

94

CD107a

LAMP1_HUMAN

LAMP1

 

P11279

Lysosome-associated membrane glycoprotein 1 (LAMP-1) (Lysosome-associated membrane protein 1) (CD107 antigen-like family member A) (CD antigen CD107a)

95

CD108

SEM7A_HUMAN

SEMA7A

CD108 SEMAL

O75326

Semaphorin-7A (CDw108) (JMH blood group antigen) (John-Milton-Hargen human blood group Ag) (Semaphorin-K1) (Sema K1) (Semaphorin-L) (Sema L) (CD antigen CD108)

96

CD117

KIT_HUMAN

KIT

SCFR

P10721

Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117)

97

CD122

IL2RB_HUMAN

IL2RB

IL15RB

P14784

Interleukin-2 receptor subunit beta (IL-2 receptor subunit beta) (IL-2R subunit beta) (IL-2RB) (High affinity IL-2 receptor subunit beta) (Interleukin-15 receptor subunit beta) (p70-75) (p75) (CD antigen CD122)

98

CD123

IL3RA_HUMAN

IL3RA

IL3R

P26951

Interleukin-3 receptor subunit alpha (IL-3 receptor subunit alpha) (IL-3R subunit alpha) (IL-3R-alpha) (IL-3RA) (CD antigen CD123)

99

CD126

IL6RA_HUMAN

IL6R

 

P08887

Interleukin-6 receptor subunit alpha (IL-6 receptor subunit alpha) (IL-6R subunit alpha) (IL-6R-alpha) (IL-6RA) (IL-6R 1) (Membrane glycoprotein 80) (gp80) (CD antigen CD126)

100

CD127

IL7RA_HUMAN

IL7R

 

P16871

Interleukin-7 receptor subunit alpha (IL-7 receptor subunit alpha) (IL-7R subunit alpha) (IL-7R-alpha) (IL-7RA) (CDw127) (CD antigen CD127)

101

CDw131

IL3RB_HUMAN

CSF2RB

IL3RB IL5RB

P32927

Cytokine receptor common subunit beta (CDw131) (GM-CSF/IL-3/IL-5 receptor common beta subunit) (CD antigen CD131)

102

CD134

TNR4_HUMAN

TNFRSF4

TXGP1L

P43489

Tumor necrosis factor receptor superfamily member 4 (ACT35 antigen) (OX40L receptor) (TAX transcriptionally-activated glycoprotein 1 receptor) (CD antigen CD134)

103

CD137

TNR9_HUMAN

TNFRSF9

CD137 ILA

Q07011

Tumor necrosis factor receptor superfamily member 9 (4-1BB ligand receptor) (CDw137) (T-cell antigen 4-1BB homolog) (T-cell antigen ILA) (CD antigen CD137)

104

CD138

SDC1_HUMAN

SDC1

SDC

P18827

Syndecan-1 (SYND1) (CD antigen CD138)

105

CD139

     

106

CD147

BASI_HUMAN

BSG

 

P35613

Basigin (5F7) (Collagenase stimulatory factor) (Extracellular matrix metalloproteinase inducer) (EMMPRIN) (Leukocyte activation antigen M6) (OK blood group antigen) (Tumor cell-derived collagenase stimulatory factor) (TCSF) (CD antigen CD147)

107

CD150

SLAF1_HUMAN

SLAMF1

SLAM

Q13291

Signaling lymphocytic activation molecule (CDw150) (IPO-3) (SLAM family member 1) (CD antigen CD150)

108

CD152

CTLA4_HUMAN

CTLA4

CD152

P16410

Cytotoxic T-lymphocyte protein 4 (Cytotoxic T-lymphocyte-associated antigen 4) (CTLA-4) (CD antigen CD152)

109

CD153

TNFL8_HUMAN

TNFS8

CD30L, CD30LG

P32971

Tumor necrosis factor ligand superfamily member 8 (CD30 ligand) (CD30-L) (CD antigen CD153)

110

CD158

KI2L2_HUMAN

KIR2DL2

CD158B1 NKAT6

P43627

Killer cell immunoglobulin-like receptor 2DL2 (CD158 antigen-like family member B1) (MHC class I NK cell receptor) (Natural killer-associated transcript 6) (NKAT-6) (p58 natural killer cell receptor clone CL-43) (p58 NK receptor CL-43) (CD antigen CD158b1)

111

CD162

SELPL_HUMAN

SELPLG

 

Q14242

P-selectin glycoprotein ligand 1 (PSGL-1) (Selectin P ligand) (CD antigen CD162)

112

CD16B

FCG3B_HUMAN

FCGR3B

CD16B FCG3 FCGR3 IGFR3

O75015

Low affinity immunoglobulin gamma Fc region receptor III-B (Fc-gamma RIII-beta) (Fc-gamma RIII) (Fc-gamma RIIIb) (FcRIII) (FcRIIIb) (FcR-10) (IgG Fc receptor III-1) (CD antigen CD16b)

113

CD177

CD177_HUMAN

CD177

NB1 PRV1

Q8N6Q3

CD177 antigen (Human neutrophil alloantigen 2a) (HNA-2a) (NB1 glycoprotein) (NB1 GP) (Polycythemia rubra vera protein 1) (PRV-1) (CD antigen CD177)

114

CD185

CXCR5_HUMAN

CXCR5

BLR1 MDR15

P32302

C-X-C chemokine receptor type 5 (CXC-R5) (CXCR-5) (Burkitt lymphoma receptor 1) (Monocyte-derived receptor 15) (MDR-15) (CD antigen CD185)

115

CD197

CCR7_HUMAN

CCR7

CMKBR7 EBI1 EVI1

P32248

C-C chemokine receptor type 7 (C-C CKR-7) (CC-CKR-7) (CCR-7) (BLR2) (CDw197) (Epstein-Barr virus-induced G-protein coupled receptor 1) (EBI1) (EBV-induced G-protein coupled receptor 1) (MIP-3 beta receptor) (CD antigen CD197)

116

CD202b

TIE2_HUMAN

TEK

TIE2 VMCM VMCM1

Q02763

Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (Tunica interna endothelial cell kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TEK) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (p140 TEK) (CD antigen CD202b)

117

CD205

LY75_HUMAN

LY75

CD205 CLEC13B

O60449

Lymphocyte antigen 75 (Ly-75) (C-type lectin domain family 13 member B) (DEC-205) (gp200-MR6) (CD antigen CD205)

118

CD222

MPRI_HUMAN

IGF2R

MPRI

P11717

Cation-independent mannose-6-phosphate receptor (CI Man-6-P receptor) (CI-MPR) (M6PR) (300 kDa mannose 6-phosphate receptor) (MPR 300) (Insulin-like growth factor 2 receptor) (Insulin-like growth factor II receptor) (IGF-II receptor) (M6P/IGF2 receptor) (M6P/IGF2R) (CD antigen CD222)

119

CD223

LAG3_HUMAN

LAG3

FDC

P18627

Lymphocyte activation gene 3 protein (LAG-3) (Protein FDC) (CD antigen CD223)

120

CD235a

GLPA_HUMAN

GYPA

GPA

P02724

Glycophorin-A (MN sialoglycoprotein) (PAS-2) (Sialoglycoprotein alpha) (CD antigen CD235a)

121

CD235ab

GLPB_HUMAN

GYPB

GPB

P06028

Glycophorin-B (PAS-3) (SS-active sialoglycoprotein) (Sialoglycoprotein delta) (CD antigen CD235b)

122

CD252

TNFL4_HUMAN

TNFSF4

TXGP1

P23510

Tumor necrosis factor ligand superfamily member 4 (Glycoprotein Gp34) (OX40 ligand) (OX40L) (TAX transcriptionally-activated glycoprotein 1) (CD antigen CD252)

123

CD268

TR13C_HUMAN

TNFRSF13C

BAFFR BR3

Q96RJ3

Tumor necrosis factor receptor superfamily member 13C (B-cell-activating factor receptor) (BAFF receptor) (BAFF-R) (BLyS receptor 3) (CD antigen CD268)

124

CD272

BTLA_HUMAN

BTLA

 

Q7Z6A9

B- and T-lymphocyte attenuator (B- and T-lymphocyte-associated protein) (CD antigen CD272)

125

CD274

PD1L1_HUMAN

CD274

B7H1 PDCD1L1 PDCD1LG1 PDL1

Q9NZQ7

Programmed cell death 1 ligand 1 (PD-L1) (PDCD1 ligand 1) (Programmed death ligand 1) (B7 homolog 1) (B7-H1) (CD antigen CD274)

126

CD276

CD276_HUMAN

CD276

B7H3

Q5ZPR3

CD276 antigen (4Ig-B7-H3) (B7 homolog 3) (B7-H3) (Costimulatory molecule) (CD antigen CD276)

127

CD278

ICOS_HUMAN

ICOS

AILIM

Q9Y6W8

Inducible T-cell costimulator (Activation-inducible lymphocyte immunomediatory molecule) (CD antigen CD278)

128

CD279

PDCD1_HUMAN

PDCD1

PD1

Q15116

Programmed cell death protein 1 (Protein PD-1) (hPD-1) (CD antigen CD279)

129

CD357

TNR18_HUMAN

TNFRSF18

AITR GITR

Q9Y5U5

Tumor necrosis factor receptor superfamily member 18 (Activation-inducible TNFR family receptor) (Glucocorticoid-induced TNFR-related protein) (CD antigen CD357)

 

 

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scioPhospho: protein profiling and phosphorylation status

scioPhospho: protein profiling and phosphorylation status

scioPhospho combines the advantages of a robust and cost-efficient protein expression profiling using scioDiscover with information on phosphorylation status. This combination provides a comprehensive overview on signalling events and pathway activity regulation. Features 900 highly relevant proteins are profiled in a single assay Phosphorylation status combined with protein expression levels…
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News

Meeting | Sciomics @ CRUK Brain Cancer Conference 2018

| May 1-3 2018 | Meet Dr. Ronny Schmidt  in London at the Cancer Research UK Brain Cancer Conference 2018 to learn more about our analysis services for protein as well as posttranslational modification profilings.

Meeting | Sciomics @ Oxford Immunology Symposium

| April 16-17 2018 | Visit our booth and meet Dr. Ronny Schmidt  to learn more about our protein profiling services to better understand the different mechanism in immunology.

New article | Role of Corneal Stromal Cells on Epithelial Cell Function during Wound Healing

| February 2018 | Researchers at Rostock University Medical Center published an article on the role of Corneal Stromal Cells on Epithelial Cell Function during Wound Healing in the International Journal of Molecular Sciences.

> Customer Testimonial Bhavani Kowtharapu:

"I am really happy with service of Sciomics. Very friendly team and really fast service and we have the results in our hand including bioinformatics analysis within 2 weeks. Thank you Sciomics team."

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Research | Participation in collaborative clinical studies for the treatment of MCDS

| January 2018 | The multinational consortium MCDS-therapy has been granted 5.7 Million Euro by the European Commission for the development of novel therapeutic approaches in rare skeletal disorders. Sciomics' expertise with the antibody microarray technology herein serves as a valuable tool for biomarker identification and personalized treatment monitoring. > Press release

New article | Modeling Congenital Adrenal Hyperplasia and Testing Interventions for Adrenal Insufficiency Using Donor-Specific Reprogrammed Cells

| January 2018 | A scioDiscover protein microarray study contributed to an article in Cell Reports. In this study Gerard Ruiz-Babot et al. analysed a donor specific reprogramming of cells.

Customer testimonial Leonardo Guasti, PhD (senior author):

This has undoubtedly opened new avenues in our research. We have found the Sciomics team to be extremely helpful and efficient during the whole process, from advising the best strategy to the final interpretation of results.

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A glas full of hope | Ein Glas Hoffnung

| January 2018 | Article on the StartUp Sciomics and our antibody microarray platform by our partner SCHOTT nexterion.

> English version "A glass full of hope"

> Deutsche Version "Ein Glas Hoffnung"

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