Sciomics participates in collaborative clinical trials for the treatment of metaphyseal chondrodysplasia type Schmid (MCDS)

See below for German version

Heidelberg, 12th February, 2018

 

Multinational consortium has been granted 5.7 Million Euro for the development of novel therapeutic approaches in rare skeletal disorders. Sciomics' expertise with the antibody microarray technology herein serves as a valuable tool for biomarker identification and personalized treatment monitoring.

The biotechnology company Sciomics GmbH, located in Heidelberg, Germany, today announced its participation in the multinational clinical project 'MCDS Therapy'. This five-year collaborative study comprises both world-renowned clinical centres as well as small and medium-sized enterprises in the EU and Australia with a total funding of 5.7 Million Euro. In successive clinical trials, the re-purposing of the drug carbamazepine (CBZ) for the treatment of the skeletal disease metaphyseal chondrodysplasia type Schmid (MCDS) will be investigated. Furthermore, 'MCDS Therapy' encompasses biomarker development and health economics assessment studies to deliver an innovative and affordable therapy for MCDS, along with diagnostic and prognostic tools to personalize the treatment.

MCDS is a skeletal disorder resulting in short stature, abnormally shortened or bowed limbs, chronic pain and decreased mobility. Less than 1 in 100,000 people is affected, which renders the disease a so-called orphan disease. The disease is incurable, and MCDS patients rely on the long-term use of pain therapy and usually undergo numerous orthopaedic surgical interventions to correct knee and hip deformities. This burden in pain and disability leads to poor quality of life and extensive healthcare costs.

CBZ received orphan drug designation by the European Commission for the treatment of MCDS in 2016. 'MCDS Therapy' aims at advancing the re-purposing of CBZ to deliver the first non-surgical therapeutic intervention for MCDS. During the course of the project, an assessment of relevant biomarkers will be incorporated. The aim is to discover novel biomarkers that are directly relevant to CBZ treatment of MCDS which can then be used to monitor therapy and are potentially applicable to a broader group of genetic skeletal diseases or human connective tissue disease in general. 'MCDS Therapy' will use a high-content screening approaches to discover panels of potential biomarkers using samples from both mouse models and patient-derived samples. Herein, Sciomics' antibody microarrays serve as a crucial tool to identify and validate biomarkers for diagnosis, prognosis and personalized therapy.

Sciomics GmbH was founded in 2013 as a spin-off company of the German Cancer Research Centre (DKFZ). 'We are glad to participate in this highly innovative project with our solid expertise in antibody microarrays', states Dr. Christoph Schroeder, CEO of Sciomics. 'Accounting for the hallmarks of our microarray technology, which include high throughput, flexibility, multiplex analysis and robustness, I am convinced that our contribution to this novel treatment option for MCDS will be of great service. Especially for the patients suffering from this severe illness.'

> Download press release as PDF-file

 

 

Heidelberg, 12. Februar 2018

Sciomics an klinischen Studien für die Behandlung von Metaphysärer Chondrodysplasie Typ Schmid (MCDS) beteiligt

Multinationales Konsortium mit einem Gesamtbudget von 5,7 Millionen Euro entwickelt neue therapeutische Ansätze für seltene Knochenerkrankungen. Hierbei spielen die Antikörper-Microarrays von Sciomics eine zentrale Rolle bei der Identifizierung von Biomarkern und Personalisierung der Therapie.

Das Biotechnologie-Unternehmen Sciomics GmbH mit Sitz in Heidelberg teilte heute seine Beteiligung an dem multinationalen klinischen Projekt „MCDS Therapy” mit. An dem Kooperationprojekt mit einem Gesamtbudget von 5,7 Millionen Euro über fünf Jahre arbeiten sowohl renommierte klinische Zentren als auch kleinere und mittelständische Unternehmen aus der EU und Australien mit. In mehreren klinischen Studien soll hierbei die Verwendung des Medikamentes Carbamazepin (CBZ) zur Behandlung der Knochenerkrankung Metaphysäre Chondrodysplasie Typ Schmid (MCDS) untersucht werden. Ein wichtiger Teil der Studien ist die Identifizierung und Validierung von Biomarkern für Diagnose, Prognose und personalisierte Therapie sowie gesundheitswirtschaftliche Aspekte, um eine innovative und kostengünstige Therapie für MCDS zu entwickeln.

MCDS ist eine Knochenerkrankung, deren Symptome Kleinwüchsigkeit, verkürzte und gekrümmte Extremitäten, chronische Schmerzen und eine eingeschränkte Beweglichkeit sind. Weniger als eine von 100.000 Personen ist davon betroffen; es handelt sich bei MCDS somit um eine sogenannte „Orphan Disease“. Die Krankheit ist unheilbar; MCDS-Patienten sind somit ihr Leben lang auf Schmerztherapie sowie orthopädische Behandlung angewiesen. Die chronischen Schmerzen und Behinderungen führen bei den Patienten zu einer geringen Lebensqualität und hohen Behandlungskosten.

CBZ hat 2016 die „Orphan Drug Designation“ der Europäischen Kommission für MCDS erhalten. Ziel von „MCDS Therapy“ ist es, mit der Verwendung von CBZ die erste nicht-invasive Therapie für MCDS zu entwickeln.Ein wichtiger Aspekt des Projekts ist die Identifizierung und Validierung von Biomarkern, die eine direkte Relevanz für die CBZ-Behandlung von MCDS haben. Diese könnten für die Therapieüberwachung von MCDS eingesetzt werden und möglicherweise auch auf andere genetisch bedingte Knochen- und Bindegewebserkrankungen übertragen werden. Im Zuge von „MCDS Therapy“ werden sowohl Proben aus Mausmodellen, als auch von MCDS-Patienten untersucht. Hierbei dienen die Antikörper-Microarrays von Sciomics als wichtige Werkzeuge bei der Identifizierung und Validierung von Biomarkern für Diagnose, Prognose und personalisierte Therapie.

Sciomics wurde 2013 als Spin-Off des Deutschen Krebsforschungszentrums (DKFZ) gegründet. „Wir freuen uns sehr, mit unserer langjährigen Microarray-Expertise zu diesem hochinnovativen Projekt beitragen zu können“, sagt Dr. Christoph Schröder, Geschäftsführer der Sciomics GmbH. „Angesichts der Vorteile unserer Antikörper-Microarrays, wie hoher Durchsatz, Flexibilität, hochparallele Analyse und Reproduzierbarkeit, werden wir einen wichtigen Beitrag zu neuen Therapieoptionen für MCDS leisten.”

 

> Pressemitteilung als PDF

 

Sciomics GmbH
Dr. Christoph Schröder
Im Neuenheimer Feld 583
D-69120 Heidelberg
Germany

Phone: +49 (0) 6221 42948-30
Fax : +49 (0) 6221 42948-34
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
Web: http://www.sciomics.de

 

Do you like to subscribe our newsletter ?      Yes   No

Our service portfolio

scioPhospho: protein profiling and phosphorylation status

scioPhospho: protein profiling and phosphorylation status

scioPhospho combines the advantages of a robust and cost-efficient protein expression profiling using scioDiscover with information on phosphorylation status. This combination provides a comprehensive overview on signalling events and pathway activity regulation. Features 1030 highly relevant proteins are profiled in a single assay Phosphorylation status combined with protein expression levels…
Read more
scioDiscover - Protein Profiling on expression level

scioDiscover - Protein Profiling on expression level

Knowledge about protein expression levels is of utmost importance to predict toxic effects, estimate adverse effects of drug candidates and to identify new drug targets. Sciomics has a highly optimised…
scioCD - Cell surface marker and Cytokine profiling

scioCD - Cell surface marker and Cytokine profiling

Characterise a certain cell type ? Cell composition in a certain tissue sample ? In-depth profiling of CD-marker expression ? Increase your throughput at high sensitivity levels ? You aim…
scioSpot - Microarray Production

scioSpot - Microarray Production

Microarrays - tailor-made for you. With more than 10 years of experience, Sciomics is the ideal partner for designing and printing your antibody-, protein-, peptide- or DNA/RNA chips. Benefit from…
scioCyto

scioCyto

Cytokine profiling scioCyto is a high-content analysis service for cytokine and chemokine profiling.A great variety of samples such as plasma, tissue or cells can be used in this robust assay…
Cytokines and chemokines analyzed with scioCyto

Cytokines and chemokines analyzed with scioCyto

  Analyze 54 cytokines and chemokines in parallel Uniprot Entry HGNC Gene names (synonym) Uniprot ID Protein names CCL2_HUMAN CCL2 MCP1, SCYA2 P13500 C-C motif chemokine 2 (HC11) (Monocyte chemoattractant…

News

New article | Activated Eosinophils Exert Antitumorigenic Activities in Colorectal Cancer

| Jan 2019 | In the article, scientists at Tel Aviv University used our scioDiscover platform to analyse tumor-associated eosinophils in colorectal cancer. The full article is published in Cancer Immunology Research.

 

New article | Macrophage-derived IL-1β and TNF-α regulate arginine metabolism in neuroblastoma

| Decembre 2018 | Study by our collaborator Dr Francis Mussai at University of Birmingham suggests arginine metabolism as a target for neuroblastoma therapy. At Sciomics we are proud of having contributed to this exciting study by a scioDiscover protein profiling study. The article is published in Cancer Research.

 

New article | Protection from ischemia reperfusion injury-induced inflammation and fibrosis in C5aR2-deficient mice

| June 2018 | Complement component 5a receptor 2 (C5AR2) deficient mice are protected from inflammation and fibrosis in response to ischemia reperfusion injury. Our scioPhospho platform supported scientists at the Medical School Hannover to elucidate the underlying mechanism. The data were recently published in Kidney International.

 

New article | Modeling Congenital Adrenal Hyperplasia and Testing Interventions for Adrenal Insufficiency Using Donor-Specific Reprogrammed Cells

| January 2018 | A scioDiscover protein microarray study contributed to an article in Cell Reports. In this study Gerard Ruiz-Babot et al. analysed a donor specific reprogramming of cells.

Customer testimonial Leonardo Guasti, PhD (senior author):

This has undoubtedly opened new avenues in our research. We have found the Sciomics team to be extremely helpful and efficient during the whole process, from advising the best strategy to the final interpretation of results.

> More testimonials

A glas full of hope | Ein Glas Hoffnung

| January 2018 | Article on the StartUp Sciomics and our antibody microarray platform by our partner SCHOTT nexterion.

> English version "A glass full of hope"

> Deutsche Version "Ein Glas Hoffnung"

New article | Role of Corneal Stromal Cells on Epithelial Cell Function during Wound Healing

| February 2018 | Researchers at Rostock University Medical Center published an article on the role of Corneal Stromal Cells on Epithelial Cell Function during Wound Healing in the International Journal of Molecular Sciences.

> Customer Testimonial Bhavani Kowtharapu:

"I am really happy with service of Sciomics. Very friendly team and really fast service and we have the results in our hand including bioinformatics analysis within 2 weeks. Thank you Sciomics team."

> More testimonials

Research | Participation in collaborative clinical studies for the treatment of MCDS

| January 2018 | The multinational consortium MCDS-therapy has been granted 5.7 Million Euro by the European Commission for the development of novel therapeutic approaches in rare skeletal disorders. Sciomics' expertise with the antibody microarray technology herein serves as a valuable tool for biomarker identification and personalized treatment monitoring. > Press release

Tweets

  • yesterday

    Looking for #biomarkers to distinguish responding from non-responding patients undergoing anti-PD1 checkpoint inhib… https://t.co/JUbDTd30qE

  • 5 days ago

    RT @MCDS_Therapy: What is a #biomarker and why is the MCDS-Therapy team trying to find one? @sciomics, our partner focusing on this, have w…

  • 6 days ago

    RT @boettcher_lab: We're looking for a skilled and motivated lab manager/technician to join the lab. Please share if you know someone who's…

  • 8 days ago

    Want to investigate pathway activation with more than 1000 proteins on expression and phosphorylation level in one… https://t.co/jEagQpDsdE

  • 28 days ago

    RT @RonnySchmidt84: Cell lines, not only HeLa, need to be characterised on protein level to avoid this high degree of variability and to en…