Accelerated research is the best opportunity to increase the understanding of COVID-19 disease and efficiently fighting the novel coronavirus SARS-CoV-2. Testing multiple proteins in parallel accelerates your research and enables in-depth insights regarding the underlying molecular mechanisms.
Learn here how multiplex protein profiling can support your COVID-19 research. All information is also available as a pdf.
Immune Response Profiling & Biomarker Discovery
> Immune Response Profiling
Explore how the immune system reacts to a SARS-CoV-2 infection in different age groups, risk groups and certain individuals. Are there common mechanisms which can be used for preventing severe disease ? A parallel profiling of 121 cytokines / chemokines and 141 cell surface markers can provide novel insights. Such analyses are possible from patient samples (plasma / serum), cell culture as well as animal models.
> Disease Severity biomarkers for COVID-19
Discover new biomarkers for COVID-19 patient stratification, early prevention and improvement of disease management by multiplex screens from plasma or serum samples.< scioDiscover >
> Outcome Prediction after positive SARS-CoV-2 test
Identify risk factors and correlating protein biomarkers indicating severe COVID-19 progression for improved disease management.< scioDiscover >
Development of therapeutics against COVID-19
> Benchmarking of Therapeutics & Drug Repurposing
Accelerate your COVID-19 research by assessing pathway activity, early toxicology and mechanisms of action for an efficient benchmarking of compounds or drug repurposing candidates.
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> Therapy Response biomarkers
Identify predictive biomarkers for your COVID-19 drug candidate to stratify responders from non-responders
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Development of vaccines against SARS-CoV-2
> SARS-CoV-2 vaccine development
In-depth analysis of responses to vaccine candidates from animal and patient samples. Analyses are possible from plasma / serum samples or from purified immune cells.< scioCD > < scioDiscover > < scioPhospho >
> Profiling of animal models
> Screening of viral SARS-CoV-2 epitopes
Analyse the antibody response to different vaccine candidates in animal models and patients using plasma/serum samples.
Analyse serum samples from COVID-19 patients to identify highly immunogenic epitopes.
scioCD - 121 cytokines and 141 CD cell surface markers for immune profiling
Parallel profiling of 121 cytokines / chemokines and 141 CD cell surface markers from plasma/serum, immune cells or tissue samples.
scioDiscover - screening of 1,300 proteins in parallel
The protein panel for biomarker discovery on plasma/serum, cell or tissue samples include
- inflammatory mediators
- immune checkpoint molecules
- immune cells markers
- soluble proteins
- membrane/receptor proteins
- intracellular proteins
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scioPhospho - combined phosphorylation and expression profiling of 1,300 proteins
Combine a scioDiscover screen with information on phosphorylation status for all 1,300 proteins in one assay. Typical applications are mode-of-action studies, pathway activity profiling or mechanistic understanding of disease as well as therapeutic response.
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Common assay specifications
- Minimal sample amount required (20 µL plasma/serum, 500,000 cells, 10mg of tissue)
- Complete analysis service from sample to study report
- All assays can be complemented by a SARS-CoV-2 proteome wide peptide array < more information >